2114365-78-3
2114365-78-3 structure
- Name: Hetrombopag
- Chemical Name: Hetrombopag
- CAS Number: 2114365-78-3
- Molecular Formula: C25H22N4O5
- Molecular Weight: 458.474
- Catalog: Signaling Pathways Immunology/Inflammation Thrombopoietin Receptor
- Create Date: 2020-01-20 18:42:56
- Modify Date: 2024-01-05 16:00:42
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Hetrombopag is a potent, selective, orally-active Thrombopoietin (TPO) receptor agonist; specifically stimulates proliferation and/or differentiation of human TPOR-expressing cells, including 32D-MPL and human hematopoietic stem cells, with low nanomolar EC50 values through stimulation of STAT, PI3K and ERK signalling pathways; specifically enhances the viability and promoted the growth of 32D-MPL cells in hollow fibres implanted in nude mice, exhibiting much higher potency than eltrombopag in vivo. Other Indication Phase 2 Clinical
| Name | Hetrombopag |
|---|
| Description | Hetrombopag is a potent, selective, orally-active Thrombopoietin (TPO) receptor agonist; specifically stimulates proliferation and/or differentiation of human TPOR-expressing cells, including 32D-MPL and human hematopoietic stem cells, with low nanomolar EC50 values through stimulation of STAT, PI3K and ERK signalling pathways; specifically enhances the viability and promoted the growth of 32D-MPL cells in hollow fibres implanted in nude mice, exhibiting much higher potency than eltrombopag in vivo. Other Indication Phase 2 Clinical |
|---|---|
| References | References 1. Zhou N, et al. Cardiovasc Drugs Ther. 2016 Dec;30(6):567-577. 2. Xie C, et al. J Cell Mol Med. 2018 Nov;22(11):5367-5377. View Related Products by Target Thrombopoietin Receptor (CD110) Other Indication |
| Molecular Formula | C25H22N4O5 |
|---|---|
| Molecular Weight | 458.474 |