100845-83-8

100845-83-8 structure

100845-83-8 structure

Name: SQ28603
Chemical Name: 3-[(2-benzyl-3-sulfanylpropanoyl)amino]propanoic acid
CAS Number: 100845-83-8
Molecular Formula: C₁₃H₁₇NO₃S
Molecular Weight: 267.34400
Catalog: Signaling Pathways Metabolic Enzyme/Protease Neprilysin
Create Date: 2016-03-17 15:15:12
Modify Date: 2024-01-02 10:37:35
SQ28603 is a potent and selective inhibitor of neutral endopeptidase 3.4.24.11 (NEP), an enzyme that degrades atrial natriuretic peptide (ANP).

Name	3-[(2-benzyl-3-sulfanylpropanoyl)amino]propanoic acid
Synonyms	sq 28,603 SQ28603

Description	SQ28603 is a potent and selective inhibitor of neutral endopeptidase 3.4.24.11 (NEP), an enzyme that degrades atrial natriuretic peptide (ANP).
Related Catalog	Signaling Pathways >> Metabolic Enzyme/Protease >> Neprilysin Research Areas >> Metabolic Disease
Target	NEP[1]
In Vivo	In conscious deoxycorticosterone acetate (DOCA)/salt hypertensive rats, 300 μmol/kg, i.v., of SQ28603 significantly lowers mean arterial pressure (MAP) from 177±12 to 154±8 mm Hg and increases urinary cyclic guanosine monophosphate (GMP) excretion from 204±70 to 1,068±326 pmol/kg/min within 2 h. SQ28603 also significantly reduces NEP activity by 95% in the kidneys (1.28±0.08 vs. 18.35±0.61 μmol/min after SQ28603 and vehicle respectively) and by 77% in the lungs (0.29±0.03 vs. 0.92±0.14 μmol/kg after SQ28603 and vehicle, respectively). In conclusion, inhibition of NEP activity by SQ28603 significantly decreases MAP and increases plasma ANP concentrations and urinary excretion of cyclic GMP in conscious DOCA/salt hypertensive rats[1]. The potent neutral endopeptidase inhibitor SQ28603 significantly increases excretion of sodium from 4.9±2.3 to 14.3±2.1 muequiv./min and cyclic 3',5'-guanosine monophosphate from 118±13 to 179±18 pmol/min after intravenous administration of 300 μmol/kg (approximately 80 mg/kg) in conscious female cynomolgus monkeys[2].
References	[1]. Seymour AA, et al. Antihypertensive and renal activity of SQ 28,603, an inhibitor of neutral endopeptidase. J Cardiovasc Pharmacol. 1991 Feb;17(2):296-304. [2]. Seymour AA, et al. Evaluation of SQ 28,603, an inhibitor of neutral endopeptidase, in conscious monkeys. Can J Physiol Pharmacol. 1991 Oct;69(10):1609-17.

Density	1.216g/cm3
Boiling Point	533.3ºC at 760mmHg
Molecular Formula	C₁₃H₁₇NO₃S
Molecular Weight	267.34400
Flash Point	276.3ºC
Exact Mass	267.09300
PSA	108.69000
LogP	2.20630
Vapour Pressure	3.34E-12mmHg at 25°C
Index of Refraction	1.569
Storage condition	2-8℃