Chrysomycin A
Modify Date: 2024-01-02 14:24:05
Chrysomycin A structure
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Common Name | Chrysomycin A | ||
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| CAS Number | 82196-88-1 | Molecular Weight | 508.517 | |
| Density | 1.4±0.1 g/cm3 | Boiling Point | 799.7±60.0 °C at 760 mmHg | |
| Molecular Formula | C28H28O9 | Melting Point | N/A | |
| MSDS | Chinese USA | Flash Point | 269.6±26.4 °C | |
Use of Chrysomycin AChrysomycin A (Chr-A), an antibiotic, can be obtained from Streptomyces. Chrysomycin A exhibits antitumor and anti-tuberculous and MRSA activities. As for glioblastoma, Chrysomycin A inhibits the proliferation, migration, and invasion of cancer cells through the Akt/GSK-3β/β-catenin signaling pathway[1]. |
| Name | Chrysomycin A |
|---|---|
| Synonym | More Synonyms |
| Description | Chrysomycin A (Chr-A), an antibiotic, can be obtained from Streptomyces. Chrysomycin A exhibits antitumor and anti-tuberculous and MRSA activities. As for glioblastoma, Chrysomycin A inhibits the proliferation, migration, and invasion of cancer cells through the Akt/GSK-3β/β-catenin signaling pathway[1]. |
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| Related Catalog | |
| In Vitro | Chrysomycin A (0.2-1.8 μM; 48 h) 具有抗胶质母细胞瘤作用，抑制 U251 和 U87-MG 人胶质母细胞瘤的细胞活力，以及迁移和侵袭[1]。 Chrysomycin A (0.2-1.8 μM; 48 h) 抑制 U251 和 U87-MG 细胞中 Akt/GSK-3β/β-Catenin 信号通路[1]。 Cell Viability Assay[1] Cell Line: U251 and U87-MG human glioblastoma Concentration: 0.2, 0.4 and 0.8 μM for U251; 0.2, 0.6 and 1.8 μM for U87-MG Incubation Time: 48 hours Result: Inhibited U251 and U87-MG with 0.475 μM and 1.77 μM, respectively. Western Blot Analysis[1] Cell Line: U251 and U87-MG human glioblastoma Concentration: 0.2, 0.4 and 0.8 μM for U251; 0.2, 0.6 and 1.8 μM for U87-MG Incubation Time: 48 hours Result: Significantly downregulated the expression of slug and MMP2. Significantly decreased the protein expression of PI3K-p85, p-PI3K-p85, Akt and p-Akt, as well as c-Myc, cyclin D1. |
| References |
| Density | 1.4±0.1 g/cm3 |
|---|---|
| Boiling Point | 799.7±60.0 °C at 760 mmHg |
| Molecular Formula | C28H28O9 |
| Molecular Weight | 508.517 |
| Flash Point | 269.6±26.4 °C |
| Exact Mass | 508.173340 |
| PSA | 138.82000 |
| LogP | 5.08 |
| Appearance of Characters | solid |
| Vapour Pressure | 0.0±3.0 mmHg at 25°C |
| Index of Refraction | 1.679 |
| Storage condition | 2-8°C |
| Water Solubility | DMF: soluble |
| Personal Protective Equipment | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
|---|---|
| RIDADR | NONH for all modes of transport |
| WGK Germany | 3 |
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Angucyclines: Biosynthesis, mode-of-action, new natural products, and synthesis.
Nat. Prod. Rep. 29(2) , 264-325, (2012) Covering: 1997 to 2010. The angucycline group is the largest group of type II PKS-engineered natural products, rich in biological activities and chemical scaffolds. This stimulated synthetic creativit... |
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The chemistry of the antibiotics chrysomycin A and B. Antitumor activity of chrysomycin A.
J. Antibiot. 35(9) , 1194-201, (1982) The yellow antibiotic chrysomycin, isolated in crystalline form in 1955, is found to consist of two closely related components, a major one, chrysomycin A, and a minor one, chrysomycin B. They differ ... |
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Antitumor activity of chrysomycins M and V.
J. Antibiot. 42(9) , 1446-8, (1989)
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| Chrysomycin V |
| 6H-Benzo(d)naphtho(1,2-b)pyran-6-one, 4-(6-deoxy-3-C-methyl-β-gulopyranosyl)-8-ethenyl-1-hydroxy-10,12-dimethoxy- |
| L-Glucitol, 2,6-anhydro-1-deoxy-6-C-(8-ethenyl-1-hydroxy-10,12-dimethoxy-6-oxo-6H-benzo[d]naphtho[1,2-b]pyran-4-yl)-4-C-methyl-, (6S)- |
| Virenomycin V |
| (6S)-2,6-Anhydro-1-deoxy-6-(1-hydroxy-10,12-dimethoxy-6-oxo-8-vinyl-6H-dibenzo[c,h]chromen-4-yl)-4-C-methyl-L-glucitol |
- Shanghai Jizhi Biochemical Technology Co., Ltd
- China
- Product Name: Chrysomycin A
- Price: ￥Inquiry/1mg
- Purity: 98.0%
- Stocking Period: Inquiry
- Contact: Liu jia
- Dayang Chem (Hangzhou) Co., Ltd.
- China
- Product Name: 6H-Benzo[d]naphtho[1,2-b]pyran-6-one,4-(6-deoxy-3-C-methyl-b-gulopyranosyl)-8-ethenyl-1-hydroxy-10,12-dimethoxy-(9CI)
- Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
- Purity: 98.0%
- Stocking Period: Inquiry
- Contact: Ms Wang
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