312631-87-1
312631-87-1 structure
- Name: 3-(3-(3,6-dichloro-9H-carbazol-9-yl)-2-hydroxypropyl)thiazolidine-2,4-dione
- Chemical Name: 10074-a4
- CAS Number: 312631-87-1
- Molecular Formula: C18H14Cl2N2O3S
- Molecular Weight: 409.28600
- Catalog: Signaling Pathways Apoptosis c-Myc
- Create Date: 2018-03-10 17:42:18
- Modify Date: 2023-01-16 20:05:59
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10074-A4 is a c-Myc inhibitor. 10074-A4 could bind to c-Myc370-409 at different sites along the peptide chain. 10074-A4 has anticancer effects[1][2].
| Name | 10074-a4 |
|---|---|
| Synonyms |
3-[3-(3,6-dichlorocarbazol-9-yl)-2-hydroxypropyl]thiazolidine-2,4-dione
3-[3-(3,6-dichloro-9H-carbazol-9-yl)-2-hydroxypropyl]-1,3-thiazolidine-2,4-dione |
| Description | 10074-A4 is a c-Myc inhibitor. 10074-A4 could bind to c-Myc370-409 at different sites along the peptide chain. 10074-A4 has anticancer effects[1][2]. |
|---|---|
| Related Catalog | |
| In Vitro | 10074-A4 shows inhibitory activity of HL-60 cells with an IC50 of 15.1 μM[1]. 10074-A4 (25-50 μM; 24 hours) arrests the cell cycle at the S-phase in a dose-dependent manner in HL-60 cells. 10074-A4 inhibits the mRNA level of the c-Myc target genes, CCND2 and CDK4[1]. 10074-A4 could bind to c-Myc370-409 at different sites along the peptide chain and its binding behavior could be described as a ‘ligand cloud’. Even in the bound state, the structure of the c-Myc370-409 peptide remained a dynamic ensemble. The 10074-A4 ligand bound at different sites throughout the c-Myc370-409 chain with different strength[2]. Cell Viability Assay[1] Cell Line: HL-60 cells Concentration: 25 μM, 50 μM Incubation Time: 24 hours Result: Arrested the cell cycle at the S-phase. |
| References |
| Molecular Formula | C18H14Cl2N2O3S |
|---|---|
| Molecular Weight | 409.28600 |
| Exact Mass | 408.01000 |
| PSA | 87.84000 |
| LogP | 4.09550 |