IZTZ-1

Modify Date: 2024-02-04 10:15:28

IZTZ-1 structure	Common Name	IZTZ-1
	CAS Number	2636771-45-2	Molecular Weight	549.73
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₃₂H₃₅N₇S	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of IZTZ-1

IZTZ-1, an imidazole-benzothiazole conjugate, is a c-MYC G4 ligand. IZTZ-1 is able to downregulate the c-MYC expression by stabilizing c-MYC G4. IZTZ-1 induces cell cycle arrest, apoptosis, thereby inhibiting cell proliferation in B16 cells. IZTZ-1 shows antitumor activity, and can be used for melanoma research[1].

Name	IZTZ-1

Description	IZTZ-1, an imidazole-benzothiazole conjugate, is a c-MYC G4 ligand. IZTZ-1 is able to downregulate the c-MYC expression by stabilizing c-MYC G4. IZTZ-1 induces cell cycle arrest, apoptosis, thereby inhibiting cell proliferation in B16 cells. IZTZ-1 shows antitumor activity, and can be used for melanoma research[1].
Related Catalog	Signaling Pathways >> Apoptosis >> Apoptosis Research Areas >> Cancer Signaling Pathways >> Apoptosis >> c-Myc
In Vivo	IZTZ-1 (0-20 mg/kg, IP, once every two days, for 10 days) effectively inhibits tumor growth in a melanoma mouse model[1].
References	[1]. Wu TY, et al. A drug-like imidazole-benzothiazole conjugate inhibits malignant melanoma by stabilizing the c-MYC G-quadruplex. Bioorg Chem. 2020 Jun;99:103866.

Molecular Formula	C₃₂H₃₅N₇S
Molecular Weight	549.73

IZTZ-1

Use of IZTZ-1

Names

IZTZ-1 Biological Activity

Chemical & Physical Properties