Name | BAY-1895344 |
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Synonyms | MFCD31561442 |
Description | BAY-1895344 is a potent, orally available and selective ATR inhibitor, with IC50 of 7 nM. Anti-tumor activity[1]. |
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Related Catalog | |
Target |
ATR:7 nM (IC50) |
In Vitro | BAY-1895344 potently inhibits the proliferation of a broad spectrum of human tumor cell lines with a median IC50 of 78 nM[1]. BAY-1895344 potently suppresses hydroxyurea-induced H2AX phosphorylation (IC50, 36 nM)[1]. |
In Vivo | BAY-1895344 shows potent anti-tumor efficacy in monotherapy in a variety of xenograft models of ovarian and colorectal cancer, and causes complete tumor remission in mantle cell lymphoma models[2]. |
References |
Molecular Formula | C20H22ClN7O |
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Molecular Weight | 411.89 |
Storage condition | -20℃ |
Hazard Codes | N |
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