Elimusertib (BAY-1895344) hydrochloride

Modify Date: 2024-01-15 09:47:36

Elimusertib (BAY-1895344) hydrochloride structure	Common Name	Elimusertib (BAY-1895344) hydrochloride
	CAS Number	1876467-74-1	Molecular Weight	411.89
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₂₀H₂₂ClN₇O	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of Elimusertib (BAY-1895344) hydrochloride

BAY-1895344 is a potent, orally available and selective ATR inhibitor, with IC50 of 7 nM. Anti-tumor activity[1].

Name	BAY-1895344
Synonym	More Synonyms

Description	BAY-1895344 is a potent, orally available and selective ATR inhibitor, with IC50 of 7 nM. Anti-tumor activity[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Cell Cycle/DNA Damage >> ATM/ATR Signaling Pathways >> PI3K/Akt/mTOR >> ATM/ATR
Target	ATR:7 nM (IC50)
In Vitro	BAY-1895344 potently inhibits the proliferation of a broad spectrum of human tumor cell lines with a median IC50 of 78 nM[1]. BAY-1895344 potently suppresses hydroxyurea-induced H2AX phosphorylation (IC50, 36 nM)[1].
In Vivo	BAY-1895344 shows potent anti-tumor efficacy in monotherapy in a variety of xenograft models of ovarian and colorectal cancer, and causes complete tumor remission in mantle cell lymphoma models[2].
References	[1]. Ulrich T. Luecking, et al. Abstract 983: Identification of potent, highly selective and orally available ATR inhibitor BAY 1895344 with favorable PK properties and promising efficacy in monotherapy and combination in preclinical tumor models. Cancer Research. July 2017 Volume 77, Issue 13 Supplement. [2]. Antje Margret Wengner, et al. Abstract 836: ATR inhibitor BAY 1895344 shows potent anti-tumor efficacy in monotherapy and strong combination potential with the targeted alpha therapy Radium-223 dichloride in preclinical tumor models. Cancer Research. July 2017 Volume 77, Issue 13 Supplement

Molecular Formula	C₂₀H₂₂ClN₇O
Molecular Weight	411.89
Storage condition	-20℃

Hazard Codes	N

MFCD31561442

DC Chemicals Limited
China
Product Name: BAY-1895344
Price: $650.0/100mg $1200.0/250mg $2400.0/1g
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: BAY-1895344
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang

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