Elimusertib (BAY-1895344) hydrochloride
Modify Date: 2024-01-15 09:47:36
Elimusertib (BAY-1895344) hydrochloride structure
|
Common Name | Elimusertib (BAY-1895344) hydrochloride | ||
|---|---|---|---|---|
| CAS Number | 1876467-74-1 | Molecular Weight | 411.89 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C20H22ClN7O | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of Elimusertib (BAY-1895344) hydrochlorideBAY-1895344 is a potent, orally available and selective ATR inhibitor, with IC50 of 7 nM. Anti-tumor activity[1]. |
| Name | BAY-1895344 |
|---|---|
| Synonym | More Synonyms |
| Description | BAY-1895344 is a potent, orally available and selective ATR inhibitor, with IC50 of 7 nM. Anti-tumor activity[1]. |
|---|---|
| Related Catalog | |
| Target |
ATR:7 nM (IC50) |
| In Vitro | BAY-1895344 potently inhibits the proliferation of a broad spectrum of human tumor cell lines with a median IC50 of 78 nM[1]. BAY-1895344 potently suppresses hydroxyurea-induced H2AX phosphorylation (IC50, 36 nM)[1]. |
| In Vivo | BAY-1895344 shows potent anti-tumor efficacy in monotherapy in a variety of xenograft models of ovarian and colorectal cancer, and causes complete tumor remission in mantle cell lymphoma models[2]. |
| References |
| Molecular Formula | C20H22ClN7O |
|---|---|
| Molecular Weight | 411.89 |
| Storage condition | -20℃ |
| Hazard Codes | N |
|---|
| MFCD31561442 |