Moxifloxacin HCl

Modify Date: 2024-01-02 16:49:47

Moxifloxacin HCl Structure
Moxifloxacin HCl structure
 Common Name Moxifloxacin HCl
CAS Number 186826-86-8 Molecular Weight 437.892
Density N/A Boiling Point 636.4ºC at 760 mmHg
Molecular Formula C21H25ClFN3O4 Melting Point N/A
MSDS Chinese USA Flash Point 338.7ºC

 Use of Moxifloxacin HCl


Moxifloxacin (Hydrochloride) is a synthetic fluoroquinolone antibiotic agent.Target: AntibacterialMoxifloxacin is an extended-spectrum fluoroquinolone which has improved coverage against gram-positive cocci and atypical pathogens compared with older fluoroquinolone agents, while retaining good activity against gram-negative bacteria. The antibacterial spectrum of moxifloxacin includes all major upper and lower respiratory tract pathogens; it is one of the most active fluoroquinolones against pneumococci, including penicillin- and macrolide-resistant strains [1]. Moxifloxacin has limited phototoxic potential. In clinical trials, moxifloxacin had clinical success rates of 88-97% and bacteriologic eradication rates of 90-97%. Moxifloxacin is a safe and effective antimicrobial that will be useful for treating acute sinusitis, acute bacterial exacerbations of chronic bronchitis, and community-acquired pneumonia [2]. Moxifloxacin possibly stimulates lipid peroxidation and enhances phagocytosis, as depicted by MDA production and survival prolongation, without being toxic as depicted by white blood cell count [3]. Clinical indications: Abdominal abscess; Acute bronchitis; Acute sinusitis; Bacterial infectionToxicity: Symptoms of overdose include CNS and gastrointestinal effects such as decreased activity, somnolence, tremor, convulsions, vomiting, and diarrhea. The minimal lethal intravenous dose in mice and rats is 100 mg/kg.

 Names

Name moxifloxacin hydrochloride
Synonym More Synonyms

 Moxifloxacin HCl Biological Activity

Description Moxifloxacin (Hydrochloride) is a synthetic fluoroquinolone antibiotic agent.Target: AntibacterialMoxifloxacin is an extended-spectrum fluoroquinolone which has improved coverage against gram-positive cocci and atypical pathogens compared with older fluoroquinolone agents, while retaining good activity against gram-negative bacteria. The antibacterial spectrum of moxifloxacin includes all major upper and lower respiratory tract pathogens; it is one of the most active fluoroquinolones against pneumococci, including penicillin- and macrolide-resistant strains [1]. Moxifloxacin has limited phototoxic potential. In clinical trials, moxifloxacin had clinical success rates of 88-97% and bacteriologic eradication rates of 90-97%. Moxifloxacin is a safe and effective antimicrobial that will be useful for treating acute sinusitis, acute bacterial exacerbations of chronic bronchitis, and community-acquired pneumonia [2]. Moxifloxacin possibly stimulates lipid peroxidation and enhances phagocytosis, as depicted by MDA production and survival prolongation, without being toxic as depicted by white blood cell count [3]. Clinical indications: Abdominal abscess; Acute bronchitis; Acute sinusitis; Bacterial infectionToxicity: Symptoms of overdose include CNS and gastrointestinal effects such as decreased activity, somnolence, tremor, convulsions, vomiting, and diarrhea. The minimal lethal intravenous dose in mice and rats is 100 mg/kg.
Related Catalog
References

[1]. Balfour, J.A. and H.M. Lamb, Moxifloxacin: a review of its clinical potential in the management of community-acquired respiratory tract infections. Drugs, 2000. 59(1): p. 115-39.

[2]. Culley, C.M., et al., Moxifloxacin: clinical efficacy and safety. Am J Health Syst Pharm, 2001. 58(5): p. 379-88.

[3]. Ioannidis, O., et al., Effect of moxifloxacin on the survival, lipid peroxidation and inflammation of immunosuppressed rats with soft tissue infection from Stenotrophomonas maltophilia. Microbiol Immunol, 2013.

 Chemical & Physical Properties

Boiling Point 636.4ºC at 760 mmHg
Molecular Formula C21H25ClFN3O4
Molecular Weight 437.892
Flash Point 338.7ºC
Exact Mass 437.151764
PSA 83.80000
LogP 3.56630
Vapour Pressure 4.56E-17mmHg at 25°C
Storage condition 2-8°C

 Safety Information

Hazard Codes Xi
RIDADR NONH for all modes of transport
RTECS VB1983750
HS Code 2933499090

 Synthetic Route

Moxifloxacin structure

Moxifloxacin

CAS#:151096-09-2

~74%

Moxifloxacin HCl Structure

Moxifloxacin HCl

CAS#:186826-86-8
Literature: CIPLA LIMITED; CURTIS, Philip, Anthony Patent: WO2008/59223 A2, 2008 ; Location in patent: Page/Page column 15-16 ;
1-cyclopropyl-6,7-difluoro-1,4-dihydro-8-methoxy-4-oxo-3-quinoline carboxylic acid-O3,O4(bis(acyloxy-O)) borate structure

1-cyclopropyl-6...

CAS#:139693-52-0
(S,S)-2,8-Diazabicyclo[4,3,0]nonane structure

(S,S)-2,8-Diaza...

CAS#:151213-40-0

~%

Moxifloxacin HCl Structure

Moxifloxacin HCl

CAS#:186826-86-8
Literature: WO2010/52726 A1, ; Page/Page column 5; 6 ;
N/A structure

N/A

CAS#:496919-99-4
(S,S)-2,8-Diazabicyclo[4,3,0]nonane structure

(S,S)-2,8-Diaza...

CAS#:151213-40-0

~73%

Moxifloxacin HCl Structure

Moxifloxacin HCl

CAS#:186826-86-8
Literature: CIPLA LIMITED; CURTIS, Philip, Anthony Patent: WO2008/59223 A2, 2008 ; Location in patent: Page/Page column 13-14 ;
Moxifloxacin hydrochloride monohydrate structure

Moxifloxacin hy...

CAS#:192927-63-2

~%

Moxifloxacin HCl Structure

Moxifloxacin HCl

CAS#:186826-86-8
Literature: WO2007/10555 A2, ; Page/Page column 15 ;
1-Cyclopropyl-6,7-difluoro-1,4-dihydro-8-methoxy-4-oxo-3-quinolinecarboxylic acid structure

1-Cyclopropyl-6...

CAS#:112811-72-0

~%

Moxifloxacin HCl Structure

Moxifloxacin HCl

CAS#:186826-86-8
Literature: EP2551268 A1, ;
(S,S)-2,8-Diazabicyclo[4,3,0]nonane structure

(S,S)-2,8-Diaza...

CAS#:151213-40-0

~%

Moxifloxacin HCl Structure

Moxifloxacin HCl

CAS#:186826-86-8
Literature: EP2551268 A1, ;
(E)-ethyl 3-(cyclopropylamino)-2-(2,4,5- trifluoro-3-methoxybenzoyl)acrylate structure

(E)-ethyl 3-(cy...

CAS#:112811-70-8

~%

Moxifloxacin HCl Structure

Moxifloxacin HCl

CAS#:186826-86-8
Literature: Spectrochimica Acta - Part A: Molecular and Biomolecular Spectroscopy, , vol. 121, p. 254 - 258
(s,s)-6-benzyl-octahydro-pyrrolo[3,4-b]pyridine dihydrochloride structure

(s,s)-6-benzyl-...

CAS#:151213-39-7

~%

Moxifloxacin HCl Structure

Moxifloxacin HCl

CAS#:186826-86-8
Literature: Spectrochimica Acta - Part A: Molecular and Biomolecular Spectroscopy, , vol. 121, p. 254 - 258
1-Cyclopropyl-6,7-difluoro-1,4-dihydro-8-methoxy-4-oxo-3-quinolinecarboxylic acid structure

1-Cyclopropyl-6...

CAS#:112811-72-0
(S,S)-2,8-Diazabicyclo[4,3,0]nonane structure

(S,S)-2,8-Diaza...

CAS#:151213-40-0

~%

Moxifloxacin HCl Structure

Moxifloxacin HCl

CAS#:186826-86-8
Literature: Spectrochimica Acta - Part A: Molecular and Biomolecular Spectroscopy, , vol. 121, p. 254 - 258

 Customs

HS Code 2933990090
Summary 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

 Articles11

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Exogenous dopamine induces dehydroepiandrosterone sulfotransferase (rSULT2A1) in rat liver and changes the pharmacokinetic profile of moxifloxacin in rats.

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 Synonyms

1-cyclopropyl-6-fluoro-1,4-dihydro-8-methoxy-7-[(4aS,7aS)-octahydro-6H-pyrrolo[3,4-b]pyridine-6-yl]-4-oxo-3-quinolinecarboxylic acid hydrochloride
BAY-12-8039
Moxifloxacinehydrochloride
3-quinolinecarboxylic acid, 1-cyclopropyl-6-fluoro-1,4-dihydro-8-methoxy-7-[(4aS,7aS)-octahydro-6H-pyrrolo[3,4-b]pyridin-6-yl]-4-oxo-, monohydrochloride
Moxifloxacin
1-Cyclopropyl-6-fluoro-8-methoxy-7-[(4aS,7aS)-octahydro-6H-pyrrolo[3,4-b]pyridin-6-yl]-4-oxo-1,4-dihydroquinoline-3-carboxylic acid hydrochloride (1:1)
Moxiflaxacin HCL
Avelox,Avalox
Moxifloxacin Hydrochloride (200 mg)
Vigamox
1-cyclopropyl-6-fluoro-8-methoxy-7-[(4aS,7aS)-octahydropyrrolo[3,4-b]pyridin-6-yl]-4-oxo-1,4-dihydroquinoline-3-carboxylic acid hydrochloride
acide 1-cyclopropyl-6-fluoro-8-méthoxy-7-[(4aS,7aS)-octahydro-6H-pyrrolo[3,4-b]pyridin-6-yl]-4-oxo-1,4-dihydroquinoléine-3-carboxylique chlorhydrate
MoxifloxacineHCl
Octegra
1-Cyclopropyl-6-fluor-8-methoxy-7-[(4aS,7aS)-octahydro-6H-pyrrolo[3,4-b]pyridin-6-yl]-4-oxo-1,4-dihydrochinolin-3-carbonsäurehydrochlorid
Izilox
1-cyclopropyl-7-(S,S)-2,8-diazabicyclo(4.3.0)-non-8-yl-6-fluoro-8-methoxy-1,4-dihydro-4-oxo-3-quinoline carboxylic acid hydrochloride
1-cyclopropyl-6-fluoro-8-methoxy-7-[(4aS,7aS)-octahydro-6H-pyrrolo[3,4-b]pyridin-6-yl]-4-oxo-1,4-dihydroquinoline-3-carboxylic acid hydrochloride
MOXIFLOXACIN HCL
Moxiflocacin hydrochloride
1-Cyclopropyl-6-fluoro-8-methoxy-7-((4aS,7aS)-octahydro-6H-pyrrolo[3,4-b]pyridin-6-yl)-4-oxo-1,4-dihydro-3-quinolinecarboxylic Acid Hydrochloride
3-Quinolinecarboxylic acid, 1-cyclopropyl-6-fluoro-1,4-dihydro-8-methoxy-7-[(4aS,7aS)-octahydro-6H-pyrrolo[3,4-b]pyridin-6-yl]-4-oxo-, hydrochloride (1:1)
MFCD00949117
Moxifloxacin hydrochloride
(1'S,6'S)-1-cyclopropyl-7-(2,8-diazabicyclo[4.3.0]non-8-yl)-6-fluoro-8-methoxy-4-oxo-(1,4-dihydroquinoline)-3-carboxylic acid hydrochloride salt
Actira
1-Cyclopropyl-6-fluoro-8-methoxy-7-[(4aS,7aS)-octahydro-6H-pyrrolo[3,4-b]pyridin-6-yl]-4-oxo-1,4-dihydro-3-quinolinecarboxylic acid hydrochloride (1:1)
1-cyclopropyl-6-fluoro-1,4-dihydro-8-methoxy-7-[(4aS,7aS)-octahydro-6H-pyrrolo-[3,4-b]pyridin-6-yl]-4-oxo-3-quinolinecarboxylic acid hydrochloride
Moxifloxacin (Hydrochloride)
Proflox
Avelox
Avalox
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Related Compounds: More...
Moxifloxacin Impurity 20 HCl
959347-97-8
Moxifloxacin Related Compound A (HCl salt form)
151282-23-4
Moxifloxacin Methyl Ester
721970-35-0
Moxifloxacin
151096-09-2
Moxifloxacin Impurity 80
2331091-31-5
Moxifloxacin iMpurity
1395471-18-7
Moxifloxacin hydrochloride monohydrate
192927-63-2
Moxifloxacin Impurity 27
172426-88-9
Moxifloxacin Acyl-b-D-glucuronide
733002-61-4
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