ATR-IN-14

Modify Date: 2024-01-10 09:52:05

ATR-IN-14 structure	Common Name	ATR-IN-14
	CAS Number	2765785-88-2	Molecular Weight	393.42
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₂₀H₂₀FN₇O	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of ATR-IN-14

ATR-IN-14 (compound 1) is a potent ATR kinase inhibitor. ATR-IN-14 inhibits ATR signaling pathways downstream CHKI protein phosphorylation, with inhibition of 98.03% at 25 nM. ATR-IN-14 shows good anticancer activity in LoVo cells, with an IC50 of 64 nM[1].

Name	ATR-IN-14

Description	ATR-IN-14 (compound 1) is a potent ATR kinase inhibitor. ATR-IN-14 inhibits ATR signaling pathways downstream CHKI protein phosphorylation, with inhibition of 98.03% at 25 nM. ATR-IN-14 shows good anticancer activity in LoVo cells, with an IC50 of 64 nM[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Cell Cycle/DNA Damage >> ATM/ATR Signaling Pathways >> PI3K/Akt/mTOR >> ATM/ATR
Target	ATR
References	[1]. Shao-hui Wang, et al. Class of 1,7-naphthyridine compounds and application thereof. WO2022063308A1.

Molecular Formula	C₂₀H₂₀FN₇O
Molecular Weight	393.42

ATR-IN-14

Use of ATR-IN-14

Names

ATR-IN-14 Biological Activity

Chemical & Physical Properties