ATR-IN-14

Names

[ CAS No. ]:
2765785-88-2

[ Name ]:
ATR-IN-14

Biological Activity

[Description]:

ATR-IN-14 (compound 1) is a potent ATR kinase inhibitor. ATR-IN-14 inhibits ATR signaling pathways downstream CHKI protein phosphorylation, with inhibition of 98.03% at 25 nM. ATR-IN-14 shows good anticancer activity in LoVo cells, with an IC50 of 64 nM[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Cell Cycle/DNA Damage >> ATM/ATR
Signaling Pathways >> PI3K/Akt/mTOR >> ATM/ATR

[Target]

ATR


[References]

[1]. Shao-hui Wang, et al. Class of 1,7-naphthyridine compounds and application thereof. WO2022063308A1.

Chemical & Physical Properties

[ Molecular Formula ]:
C20H20FN7O

[ Molecular Weight ]:
393.42

Related Compounds