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ATR-IN-10

Names

[ CAS No. ]:
2713577-93-4

[ Name ]:
ATR-IN-10

Biological Activity

[Description]:

ATR-IN-10 is a potent and highly selective inhibitor of ataxia telangiectasia mutated and Rad3-Related (ATR) kinase with an IC50 value of 2.978 μM.

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Cell Cycle/DNA Damage >> ATM/ATR

Signaling Pathways >> PI3K/Akt/mTOR >> ATM/ATR

[Target]

ATR:2.978 μM (IC50)

[References]

[1]. Bin H, et al. Discovery of a potent and highly selective inhibitor of ataxia telangiectasia mutated and Rad3-Related (ATR) kinase: Structural activity relationship and antitumor activity both in vitro and in vivo. Eur J Med Chem. 2022 Feb 12;232:114187.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₇H₂₄N₄O

[ Molecular Weight ]:
420.51

Related Compounds