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ATR-IN-4

Names

[ CAS No. ]:
2574545-45-0

[ Name ]:
ATR-IN-4

Biological Activity

[Description]:

ATR-IN-4 is a potent ATR (Ataxia telangiectasia mutated gene Rad 3-associated kinase) inhibitor. ATR-IN-4 inhibits growth of human prostate cancer cells DU145 and human lung cancer cells NCI-H460 with IC50s of 130.9 nM and 41 .33 nM, respectively. (Patent CN112142744A, compound 13)[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Cell Cycle/DNA Damage >> ATM/ATR
Signaling Pathways >> PI3K/Akt/mTOR >> ATM/ATR

[References]

[1]. Substituted fused heteroaromatic bicyclic compounds as kinase inhibitors and uses thereof. CN112142744A.

Chemical & Physical Properties

[ Molecular Formula ]:
C18H20N8O

[ Molecular Weight ]:
364.40

Related Compounds