ATR-IN-14

Modify Date: 2025-08-25 14:04:28

ATR-IN-14 structure	Common Name	ATR-IN-14
	CAS Number	2765785-88-2	Molecular Weight	393.42
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₂₀H₂₀FN₇O	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of ATR-IN-14

ATR-IN-14 (compound 1) is a potent ATR kinase inhibitor. ATR-IN-14 inhibits ATR signaling pathways downstream CHKI protein phosphorylation, with inhibition of 98.03% at 25 nM. ATR-IN-14 shows good anticancer activity in LoVo cells, with an IC50 of 64 nM[1].

Name	ATR-IN-14

Description	ATR-IN-14 (compound 1) is a potent ATR kinase inhibitor. ATR-IN-14 inhibits ATR signaling pathways downstream CHKI protein phosphorylation, with inhibition of 98.03% at 25 nM. ATR-IN-14 shows good anticancer activity in LoVo cells, with an IC50 of 64 nM[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Cell Cycle/DNA Damage >> ATM/ATR Signaling Pathways >> PI3K/Akt/mTOR >> ATM/ATR
Target	ATR
References	[1]. Shao-hui Wang, et al. Class of 1,7-naphthyridine compounds and application thereof. WO2022063308A1.

Molecular Formula	C₂₀H₂₀FN₇O
Molecular Weight	393.42
InChIKey	DWIFLVFTZABWNK-GFCCVEGCSA-N
SMILES	CC1COCCN1c1cc(-c2ccnn2C)c2c(F)cnc(-c3ccn[nH]3)c2n1

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ATR-IN-14

Use of ATR-IN-14

Names

ATR-IN-14 Biological Activity

Chemical & Physical Properties

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.