Antitumor agent-28

Modify Date: 2024-01-06 16:33:40

Antitumor agent-28 structure	Common Name	Antitumor agent-28
	CAS Number	2097499-67-5	Molecular Weight	512.62
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₂₅H₃₂N₆O₄S	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of Antitumor agent-28

Antitumor agent-28 selectively inhibits ataxia telangiectasia mutated (ATM) kinase. Antitumor agent-28 prevents ATM mediated disease and has potent anti-cancer activity[1].

Name	Antitumor agent-28

Description	Antitumor agent-28 selectively inhibits ataxia telangiectasia mutated (ATM) kinase. Antitumor agent-28 prevents ATM mediated disease and has potent anti-cancer activity[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Cell Cycle/DNA Damage >> ATM/ATR Signaling Pathways >> PI3K/Akt/mTOR >> ATM/ATR
Target	ATM ATR
In Vitro	Antitumor agent-28 inhibits ataxia telangiectasia mutated (ATM; IC50=7.6 nM; HT29 cells), ataxia telangiectasia and Rad3-related protein (ATR; IC50=18 μM; HT29 cells), PI3Ka (IC50=0.24 μM; BT474 cells). Antitumor agent-28 does not inhibit mTOR in MDA-MB-468 cells[1].
References	[1]. Kurt Gordon Pike, et al. Composés imidazo[4,5c]quinoline-2-one et leur utilisation dans le traitement du cancer. WO2017076898A1.

Molecular Formula	C₂₅H₃₂N₆O₄S
Molecular Weight	512.62