1627600-90-1

1627600-90-1 structure

Name: Antitumor agent-63
Chemical Name: Antitumor agent-63
CAS Number: 1627600-90-1
Molecular Formula: C₃₈H₄₆N₄O₁₈
Molecular Weight: 846.79
Catalog: Signaling Pathways Cell Cycle/DNA Damage Topoisomerase
Create Date: 2022-07-01 09:07:41
Modify Date: 2024-01-10 09:50:30
Antitumor agent-63 (Compound 40), a 20 (S)-O-linked camptothecin (CPT) glycoconjugate, is an antitumor agent without toxicity towards normal cells. Antitumor agent-63 shows high stability and very weak direct topoisomerase I (Topo I) inhibition[1].

Name	Antitumor agent-63

Description	Antitumor agent-63 (Compound 40), a 20 (S)-O-linked camptothecin (CPT) glycoconjugate, is an antitumor agent without toxicity towards normal cells. Antitumor agent-63 shows high stability and very weak direct topoisomerase I (Topo I) inhibition[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Cell Cycle/DNA Damage >> Topoisomerase
Target	Top1
In Vitro	Antitumor agent-63 (Compound 40) shows cytotoxicity activities with IC50 values of 1.2, 0.8, 30.5 and >100 µM against HepG2, HCT-116, SW1990 and HEK-293, respectively[1].
References	[1]. Li M, et al. Oligosaccharide-camptothecin conjugates as potential antineoplastic drugs: Design, synthesis and biological evaluation. Eur J Med Chem. 2020 Sep 15;202:112509.

Molecular Formula	C₃₈H₄₆N₄O₁₈
Molecular Weight	846.79