181427-66-7
181427-66-7 structure
- Name: β-Amyloid (10-35), amide
- Chemical Name: β-Amyloid (10-35), amide
- CAS Number: 181427-66-7
- Molecular Formula: C133H205N35O36S
- Molecular Weight: 2902.33
- Catalog: Peptides
- Create Date: 2018-08-20 04:17:04
- Modify Date: 2025-08-23 11:54:33
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β-Amyloid (10-35), amide is composed of 26 aa (10-35 residues of the Aβ peptide) and is the primary component of the amyloid plaques of Alzheimer’s disease.
| Name | β-Amyloid (10-35), amide |
|---|
| Description | β-Amyloid (10-35), amide is composed of 26 aa (10-35 residues of the Aβ peptide) and is the primary component of the amyloid plaques of Alzheimer’s disease. |
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| Related Catalog | |
| In Vitro | β-Amyloid (10-35) is selected based on the following considerations: (1) β-Amyloid (10-35) incorporates the core region, point mutations of which significantly obstruct fibril formation and have been used to generate inhibitors of fibrillogenesis; (2) β-Amyloid (10-35) retains the ability to add to bona fide Alzheimer’s plaques, in contrast to other truncated peptides, and forms fibrils morphologically similar to those of the full length peptide; (3) Of most importance, the full length peptide, Aβ(1-42), is intractable for the controlled formation of fibrils from aqueous media because at the earliest time points, some of the peptide exists as an amorphous precipitate. In contrast, the use of β-Amyloid (10-35) allows the reproducible and controlled formation of fibrils from aqueous solutions, under defined conditions of pH, ionic strength, and peptide concentration and thus yields the required homogeneous fibrils[1]. |
| References |
| Molecular Formula | C133H205N35O36S |
|---|---|
| Molecular Weight | 2902.33 |