β-Amyloid (10-35), amide

Modify Date: 2024-01-08 18:10:39

β-Amyloid (10-35), amide structure	Common Name	β-Amyloid (10-35), amide
	CAS Number	181427-66-7	Molecular Weight	2902.33
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₁₃₃H₂₀₅N₃₅O₃₆S	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of β-Amyloid (10-35), amide

β-Amyloid (10-35), amide is composed of 26 aa (10-35 residues of the Aβ peptide) and is the primary component of the amyloid plaques of Alzheimer’s disease.

Name	β-Amyloid (10-35), amide

Description	β-Amyloid (10-35), amide is composed of 26 aa (10-35 residues of the Aβ peptide) and is the primary component of the amyloid plaques of Alzheimer’s disease.
Related Catalog	Signaling Pathways >> Neuronal Signaling >> Amyloid-β Research Areas >> Neurological Disease Peptides
In Vitro	β-Amyloid (10-35) is selected based on the following considerations: (1) β-Amyloid (10-35) incorporates the core region, point mutations of which significantly obstruct fibril formation and have been used to generate inhibitors of fibrillogenesis; (2) β-Amyloid (10-35) retains the ability to add to bona fide Alzheimer’s plaques, in contrast to other truncated peptides, and forms fibrils morphologically similar to those of the full length peptide; (3) Of most importance, the full length peptide, Aβ(1-42), is intractable for the controlled formation of fibrils from aqueous media because at the earliest time points, some of the peptide exists as an amorphous precipitate. In contrast, the use of β-Amyloid (10-35) allows the reproducible and controlled formation of fibrils from aqueous solutions, under defined conditions of pH, ionic strength, and peptide concentration and thus yields the required homogeneous fibrils[1].
References	[1]. Benzinger TL, et al. Propagating structure of Alzheimer's beta-amyloid(10-35) is parallel beta-sheet with residues in exact register. Proc Natl Acad Sci U S A. 1998 Nov 10;95(23):13407-12.

Molecular Formula	C₁₃₃H₂₀₅N₃₅O₃₆S
Molecular Weight	2902.33

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China
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β-Amyloid (10-35), amide

Use of β-Amyloid (10-35), amide

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β-Amyloid (10-35), amide Biological Activity

Chemical & Physical Properties