β-Amyloid-42

Modify Date: 2024-01-01 23:11:10

β-Amyloid-42 Structure
β-Amyloid-42 structure
 Common Name β-Amyloid-42
CAS Number 107761-42-2 Molecular Weight 4514.04000
Density N/A Boiling Point N/A
Molecular Formula C203H311N55O60S Melting Point N/A
MSDS USA Flash Point N/A

 Use of β-Amyloid-42


Amyloid β-Peptide (1-42) human is a 42-amino acid peptide which plays a key role in the pathogenesis of Alzheimer disease.

 Names

Name Amyloid|A-Peptide (1-42) (human)
Synonym More Synonyms

 β-Amyloid-42 Biological Activity

Description Amyloid β-Peptide (1-42) human is a 42-amino acid peptide which plays a key role in the pathogenesis of Alzheimer disease.
Related Catalog
In Vitro Amyloid β-Peptide (1-42) human is a 42-amino acid peptide which plays a key role in the pathogenesis of Alzheimer disease. Application of Amyloid β-Peptide (1-42) human (1 to 10 μM) in the bathing solution does not change delayed rectifier K+-current and leakage current, but enhances inactivation of Са2+-current and blocks Са2+-dependent К+-current[1]. At 2.5 μM concentration, Amyloid β-Peptide (1-42) human reduces viability of SH-SY5Y cells to 65%. Results show that Amyloid β-Peptide (1-42) human localizes in both the cytoplasm and nucleus of SH-SY5Y cells after 30 min of incubation and after 8 h. In the latter, large accumulations of Amyloid β-Peptide (1-42) human are seen in the cytoplasm and in the nucleus. Increased APP mRNA levels are also detected upon Amyloid β-Peptide (1-42) human treatment[2].
Cell Assay SH-SY5Y cells are treated with biotinylated Amyloid β-Peptide (1-42) human peptide 1 μM. Cells are fixed and permeabilized with 3.3% formaldehyde containing 0.5% Triton X-100 followed by 125 mM glycine in PBS containing magnesium and calcium. Cells are blocked with 5% fetal bovine calf serum followed by the primary antibody. Biotin-Amyloid β-Peptide (1-42) human peptide is detected with the monoclonal antibody AB or alternatively with Avidin Fluor488. Nuclei are stained with DAPI. Images are obtained using an LSM 510 meta confocal microscope[2].

 Chemical & Physical Properties

Molecular Formula C203H311N55O60S
Molecular Weight 4514.04000
Exact Mass 4511.27000
PSA 1840.49000
LogP 1.35150
Storage condition −20°C

 Safety Information

Safety Phrases 24/25
RIDADR NONH for all modes of transport
WGK Germany 3
HS Code 29332900

 Articles6

More Articles
Genotype-driven isolation of enterocin with novel bioactivities from mangrove-derived Streptomyces qinglanensis 172205.

Appl. Microbiol. Biotechnol. 99 , 5825-32, (2015)

The type II polyketide synthase (PKS) natural product enterocin (1) was isolated from a mangrove-derived novel species Streptomyces qinglanensis 172205 guided by genome sequence, and its putative bios...
The carboxy terminus of the beta amyloid protein is critical for the seeding of amyloid formation: implications for the pathogenesis of Alzheimer's disease.

Biochemistry 32 , 4693-4697, (1993)

Several variants of the beta amyloid protein, differing only at their carboxy terminus (beta 1-39, beta 1-40, beta 1-42, and beta 1-43), have been identified as the major components of the cerebral am...
Induction of neuronal death by microglial AGE-albumin: implications for Alzheimer's disease.

PLoS ONE 7 , e37917, (2012)

Advanced glycation end products (AGEs) have long been considered as potent molecules promoting neuronal cell death and contributing to neurodegenerative disorders such as Alzheimer's disease (AD). In ...

 Synonyms

β-amyloid 42
Amyloid Beta-Peptide (1-42) (human)
beta-Amyloid (1-42) human
β-amyloid polypeptide 42
β-amyloid protein 42
MFCD01864012
Human β-amyloid peptide (1-42)
DAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVVIA
Bate-Amyloid （ 1-42 ） human
Amyloid β-Peptide (1-42) (human)
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Related Compounds: More...
β-Amyloid 35-42
183292-41-3
β-Amyloid 33-40
634204-57-2
β-Amyloid 1-34
186359-65-9
β-Amyloid 11-22
885323-98-8
β-Amyloid 12-20
134649-29-9
β-Amyloid 13-27
148270-13-7
β-Amyloid 18-28
112163-49-2
β-Amyloid 1-9
147529-30-4
β-Amyloid 4-10
477284-32-5
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