β-Amyloid-42
β-Amyloid-42 structure
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Common Name | β-Amyloid-42 | ||
|---|---|---|---|---|
| CAS Number | 107761-42-2 | Molecular Weight | 4514.04000 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C203H311N55O60S | Melting Point | N/A | |
| MSDS | USA | Flash Point | N/A | |
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Genotype-driven isolation of enterocin with novel bioactivities from mangrove-derived Streptomyces qinglanensis 172205.
Appl. Microbiol. Biotechnol. 99 , 5825-32, (2015) The type II polyketide synthase (PKS) natural product enterocin (1) was isolated from a mangrove-derived novel species Streptomyces qinglanensis 172205 guided by genome sequence, and its putative biosynthetic gene cluster was revealed. Its natural analogues 5... |
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The carboxy terminus of the beta amyloid protein is critical for the seeding of amyloid formation: implications for the pathogenesis of Alzheimer's disease.
Biochemistry 32 , 4693-4697, (1993) Several variants of the beta amyloid protein, differing only at their carboxy terminus (beta 1-39, beta 1-40, beta 1-42, and beta 1-43), have been identified as the major components of the cerebral amyloid deposits which are characteristic of Alzheimer's dise... |
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Induction of neuronal death by microglial AGE-albumin: implications for Alzheimer's disease.
PLoS ONE 7 , e37917, (2012) Advanced glycation end products (AGEs) have long been considered as potent molecules promoting neuronal cell death and contributing to neurodegenerative disorders such as Alzheimer's disease (AD). In this study, we demonstrate that AGE-albumin, the most abund... |
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Prostaglandin I₂ Attenuates Prostaglandin E₂-Stimulated Expression of Interferon γ in a β-Amyloid Protein- and NF-κB-Dependent Mechanism.
Sci. Rep. 6 , 20879, (2016) Cyclooxygenase-2 (COX-2) has been recently identified as being involved in the pathogenesis of Alzheimer's disease (AD). However, the role of an important COX-2 metabolic product, prostaglandin (PG) I2, in AD development remains unknown. Using mouse-derived a... |
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Genome-wide alteration of 5-hydroxymenthylcytosine in a mouse model of Alzheimer's disease.
BMC Genomics 17 , 381, (2016) Alzheimer's disease (AD) is the most common form of neurodegenerative disorder that leads to a decline in cognitive function. In AD, aggregates of amyloid β peptide precede the accumulation of neurofibrillary tangles, both of which are hallmarks of the diseas... |
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Elevated Neuronal Excitability Due to Modulation of the Voltage-Gated Sodium Channel Nav1.6 by Aβ1-42.
Front. Neurosci. 10 , 94, (2016) Aberrant increases in neuronal network excitability may contribute to the cognitive deficits in Alzheimer's disease (AD). However, the mechanisms underlying hyperexcitability are not fully understood. Such overexcitation of neuronal networks has been detected... |