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Exploring the potential of natural and synthetic neuroprotective steroids against neurodegenerative disorders: A literature review
10.1002/med.21458 2017-07-11 Neurodegeneration is a complex process, which leads to progressive brain damage due to loss of neurons. Despite exhaustive research, the cause of neuronal loss in various degenerative disorders is not entirely understood. Neuroprotective steroids constitute a... |
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A3 Adenosine Receptors as Modulators of Inflammation: From Medicinal Chemistry to Therapy
10.1002/med.21456 2017-07-06 The A3 adenosine receptor (A3AR) subtype is a novel, promising therapeutic target for inflammatory diseases, such as rheumatoid arthritis (RA) and psoriasis, as well as liver cancer. A3AR is coupled to inhibition of adenylyl cyclase and regulation of mitogen-... |
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Mitochondrial dysfunction and potential anticancer therapy
10.1002/med.21459 2017-07-06 Mitochondrial dysfunction (MDF) has been identified as an important factor in various diseases ranging from neurological disorders, to diseases of the cardiovascular system and metabolic syndromes. MDF was also found in cancer as well as in cancer predisposit... |
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Toward an Understanding of Structural Insights of Xanthine and Aldehyde Oxidases: An Overview of their Inhibitors and Role in Various Diseases
10.1002/med.21457 2017-07-03 Almost all drug molecules become the substrates for oxidoreductase enzymes, get metabolized into more hydrophilic products and eliminated from the body. These metabolites sometime may be more potent, active, inactive, or toxic in nature compared to parent mol... |
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Tumor angiogenesis revisited: Regulators and clinical implications
10.1002/med.21452 2017-06-23 Since Judah Folkman hypothesized in 1971 that angiogenesis is required for solid tumor growth, numerous studies have been conducted to unravel the angiogenesis process, analyze its role in primary tumor growth, metastasis and angiogenic diseases, and to devel... |
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Artemisinin as an anticancer drug: Recent advances in target profiling and mechanisms of action
10.1002/med.21446 2017-06-23 Artemisinin and its derivatives (collectively termed as artemisinins) are among the most important and effective antimalarial drugs, with proven safety and efficacy in clinical use. Beyond their antimalarial effects, artemisinins have also been shown to posse... |
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Progress in the synthesis and biological evaluation of lipid A and its derivatives
10.1002/med.21447 2017-06-16 Lipid A is one of the core structures of bacterial lipopolysaccharides (LPSs), and it is mainly responsible for the strong immunostimulatory activities of LPS through interactions with the Toll-like receptors and other molecules in the human immune system. To... |
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Glypican-3: A promising biomarker for hepatocellular carcinoma diagnosis and treatment
10.1002/med.21455 2017-06-16 Liver cancer is the second leading cause of cancer-related deaths, and hepatocellular carcinoma (HCC) is the most common type. Therefore, molecular targets are urgently required for the early detection of HCC and the development of novel therapeutic approache... |
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Inhibitors of kallikrein-related peptidases: An overview
10.1002/med.21451 2017-06-13 Kallikrein-related peptidases (KLKs) are a family of 15 secreted serine proteases that are involved in various physiological processes. Their activities are subtly regulated by various endogenous inhibitors, ranging from metallic ions to macromolecular entiti... |
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Small-molecule AT2 receptor agonists
10.1002/med.21449 2017-06-13 The discovery of the first selective, small-molecule ATR receptor (AT2R) agonist compound 21 (C21) (8) that is now extensively studied in a large variety of in vitro and in vivo models is described. The sulfonylcarbamate derivative 8, encompassing a phenylthi... |