Amyloid β-Protein (1-42) (mouse, rat)
Modify Date: 2025-08-20 20:03:13
Amyloid β-Protein (1-42) (mouse, rat) structure
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Common Name | Amyloid β-Protein (1-42) (mouse, rat) | ||
|---|---|---|---|---|
| CAS Number | 166090-74-0 | Molecular Weight | 4418.017 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C199H307N53O59S | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of Amyloid β-Protein (1-42) (mouse, rat)β-Amyloid (1-42), rat is a 42-aa peptide, shows cytotoxic effect on acute hippocampal slices, and used in the research of Alzheimer's disease. |
| Name | Amyloid beta-peptide (1-42) (rat) |
|---|---|
| Synonym | More Synonyms |
| Description | β-Amyloid (1-42), rat is a 42-aa peptide, shows cytotoxic effect on acute hippocampal slices, and used in the research of Alzheimer's disease. |
|---|---|
| Related Catalog | |
| Target |
Amyloid-β[1] |
| In Vitro | β-Amyloid (1-42), rat shows cytotoxic effect on the hippocampal slices at 20 μM[1]. β-Amyloid (1-42), rat causes morphological changes in NGF-induced PC12 cells, induces formed cell processes to retract in differentiated cells and affect the expression of exons 2/3 in both undifferentiated and differentiated cells[2]. |
| Cell Assay | After treating the hippocampal slices with 20 μM β-Amyloid (1-42) for 4 h, supernatant is replaced by fresh H-ASCF/3 (0.9 mL/chamber) to which 0.1 mL MTT stock solution (5 mg/mL H-ACSF/3) is added (MTT final concentration: 0.5 mg/mL). The chamber is left to rest for 15 min without carboxygenation. To stop further reduction of MTT, the medium (H-ACSF/3) is removed. The slices are transferred into 96-well plate, then pure DMSO (100 μL/slice/well) is added for dissolving formazane from the slices. (30 min in a 96-well plate). Then 70 μL DMSO solution from each slice (well) is transferred into another 96-well plate. The optical density (OD) of the dissolved formazane is measured at 550 and 620 nm[1]. |
| References |
| Molecular Formula | C199H307N53O59S |
|---|---|
| Molecular Weight | 4418.017 |
| Exact Mass | 4417.244 |
| InChIKey | HAWSUONKNKRLRH-ANECVMDESA-N |
| SMILES | CCC(C)C(NC(=O)C(C)NC(=O)CNC(=O)C(CCCCN)NC(=O)C(CC(N)=O)NC(=O)C(CO)NC(=O)CNC(=O)C(NC(=O)C(CC(=O)O)NC(=O)C(CCC(=O)O)NC(=O)C(C)NC(=O)C(Cc1ccccc1)NC(=O)C(Cc1ccccc1)NC(=O)C(NC(=O)C(CC(C)C)NC(=O)C(CCCCN)NC(=O)C(CCC(N)=O)NC(=O)C(Cc1c[nH]cn1)NC(=O)C(CCCNC(=N)N)NC(=O)C(NC(=O)C(CCC(=O)O)NC(=O)C(Cc1ccccc1)NC(=O)CNC(=O)C(CO)NC(=O)C(CC(=O)O)NC(=O)C(Cc1c[nH]cn1)NC(=O)CNC(=O)C(Cc1ccccc1)NC(=O)C(CCC(=O)O)NC(=O)C(C)NC(=O)C(N)CC(=O)O)C(C)C)C(C)C)C(C)C)C(=O)NC(C(=O)NCC(=O)NC(CC(C)C)C(=O)NC(CCSC)C(=O)NC(C(=O)NCC(=O)NCC(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C)C(=O)O)C(C)CC)C(C)C)C(C)C)C(C)C)C(C)CC |
| bap 1-42 |
| asp-ala-glu-phe-arg-his-asp-ser-gly-tyr-glu-val-his-his-gln-lys-leu-val-phe-phe-ala-glu-asp-val-gly-ser-asn-lys-gly-ala-ile-ile-gly-leu-met-val-gly-gly-val-val-ile-ala |
| predominant amyloid b-protein fragment |
| beta-amyloid peptide (1-40), mouse, rat |
| asp-ala-glu-phe-gly-his-asp-ser-gly-phe-glu-val-arg-his-gln-lys-leu-val-phe-phe-ala-glu-asp-val-gly-ser-asn-lys-gly-ala-ile-ile-gly-leu-met-val-gly-gly-val-val-ile-ala |
| beta-amyloid peptide (1-40), rat |
| beta-amyloid, sodium salt |
| beta-amyloid peptide (1-42), rat |
| β-Amyloid (1-42), rat |