(Glu20)-Amyloid β-Protein (1-42)

Modify Date: 2024-01-03 19:03:12

(Glu20)-Amyloid β-Protein (1-42) Structure
(Glu20)-Amyloid β-Protein (1-42) structure
Common Name (Glu20)-Amyloid β-Protein (1-42)
CAS Number 1802086-22-1 Molecular Weight N/A
Density N/A Boiling Point N/A
Molecular Formula N/A Melting Point N/A
MSDS N/A Flash Point N/A

 Use of (Glu20)-Amyloid β-Protein (1-42)


(Glu20)-Amyloid β-Protein (1-42) is a slower fibrillizing variant of amyloid β-protein (Aβ). The Glu20 mutation reduces the aggregation propensity of Aβ42 and prevents accumulation of the slowly fibrillizing peptide. Amyloid β-protein is the primary component of both vascular and parenchymal amyloid deposits in Alzheimer's disease[1][2].

 Names

Name (Glu20)-Amyloid β-Protein (1-42)

 (Glu20)-Amyloid β-Protein (1-42) Biological Activity

Description (Glu20)-Amyloid β-Protein (1-42) is a slower fibrillizing variant of amyloid β-protein (Aβ). The Glu20 mutation reduces the aggregation propensity of Aβ42 and prevents accumulation of the slowly fibrillizing peptide. Amyloid β-protein is the primary component of both vascular and parenchymal amyloid deposits in Alzheimer's disease[1][2].
Related Catalog
References

[1]. Poduslo JF, et al. Receptor-mediated transport of human amyloid beta-protein 1-40 and 1-42 at the blood-brain barrier. Neurobiol Dis. 1999 Jun;6(3):190-9.  

[2]. Williams TL, et al. The effect of Alzheimer's Aβ aggregation state on the permeation of biomimetic lipid vesicles. Langmuir. 2010 Nov 16;26(22):17260-8.  

 Chemical & Physical Properties

No Any Chemical & Physical Properties