HOECHST 34580
Modify Date: 2024-01-08 17:50:11
HOECHST 34580 structure
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Common Name | HOECHST 34580 | ||
|---|---|---|---|---|
| CAS Number | 23555-00-2 | Molecular Weight | 451.57 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C27H29N7 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of HOECHST 34580Hoechst 34580 is a cell-permeable fluorescent dye for staining DNA and nuclei. |
| Name | N,N-dimethyl-4-[6-[6-(4-methylpiperazin-1-yl)-1H-benzimidazol-2-yl]-1H-benzimidazol-2-yl]aniline |
|---|---|
| Synonym | More Synonyms |
| Description | Hoechst 34580 is a cell-permeable fluorescent dye for staining DNA and nuclei. |
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| Related Catalog | |
| Target |
Amyloid-β[1] |
| In Vitro | Hoechst 34580 prefers to locate near hydrophobic regions with binding affinity with the inhibition constant IC50 of 0.86±0.05 μM for Hoechst 34580. Hoechst 34580 is a good candidate for treating the Alzheimer’s disease by inhibiting Aβ formation. 50 μM Aβ42 solutions co-incubated with 100, 25, 12.5, 3.125, 0.78, and 0.1, 0.01 μM Hoechst 34580 at 37 °C for 70 h. Hoechst 34580 can inhibit the aggregation of Aβ42 in a dose-dependent manner. And the half-maximal concentration (IC50) is examined. The IC50 is obtained by measuring the concentration of Hoechst 34580 while maintaining the Aβ42 concentration which gave 0.86±0.05 μM for Hoechst 34580[1]. |
| References |
| Molecular Formula | C27H29N7 |
|---|---|
| Molecular Weight | 451.57 |
| PSA | 82.54000 |
| LogP | 5.86710 |
| Storage condition | 2-8℃ |
| 2'-(4-DIMETHYLAMINOPHENYL)-5-(4-METHYL-1-PIPERAZINYL)-2,5'-BI-BENZIMIDAZOLE |
| CS-1303 |
| N,N-dimethyl-4-[5-(4-methyl-piperazin-1-yl)-1(3)H,1'(3')H-[2,5']bibenzoimidazolyl-2'-yl]-aniline |
| BBZ |
| 4-dimethylamino-1-{5'-[5''-(4'''-methylpiperazin-1'''-yl)-1H-benzimidazol-2''-yl]-3H-benzimidazol-2'-yl}benzene |
| Proamine |
| para-dimethylamino-Hoechst |
| HOECHST 34580 |