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23555-00-2

23555-00-2 structure
23555-00-2 structure
  • Name: HOECHST 34580
  • Chemical Name: N,N-dimethyl-4-[6-[6-(4-methylpiperazin-1-yl)-1H-benzimidazol-2-yl]-1H-benzimidazol-2-yl]aniline
  • CAS Number: 23555-00-2
  • Molecular Formula: C27H29N7
  • Molecular Weight: 451.57
  • Catalog: Dye Reagents
  • Create Date: 2017-03-20 03:40:46
  • Modify Date: 2024-01-08 17:50:11
  • Hoechst 34580 is a cell-permeable fluorescent dye for staining DNA and nuclei.

Name N,N-dimethyl-4-[6-[6-(4-methylpiperazin-1-yl)-1H-benzimidazol-2-yl]-1H-benzimidazol-2-yl]aniline
Synonyms 2'-(4-DIMETHYLAMINOPHENYL)-5-(4-METHYL-1-PIPERAZINYL)-2,5'-BI-BENZIMIDAZOLE
CS-1303
N,N-dimethyl-4-[5-(4-methyl-piperazin-1-yl)-1(3)H,1'(3')H-[2,5']bibenzoimidazolyl-2'-yl]-aniline
BBZ
4-dimethylamino-1-{5'-[5''-(4'''-methylpiperazin-1'''-yl)-1H-benzimidazol-2''-yl]-3H-benzimidazol-2'-yl}benzene
Proamine
para-dimethylamino-Hoechst
HOECHST 34580
Description Hoechst 34580 is a cell-permeable fluorescent dye for staining DNA and nuclei.
Related Catalog
Target

Amyloid-β[1]

In Vitro Hoechst 34580 prefers to locate near hydrophobic regions with binding affinity with the inhibition constant IC50 of 0.86±0.05 μM for Hoechst 34580. Hoechst 34580 is a good candidate for treating the Alzheimer’s disease by inhibiting Aβ formation. 50 μM Aβ42 solutions co-incubated with 100, 25, 12.5, 3.125, 0.78, and 0.1, 0.01 μM Hoechst 34580 at 37 °C for 70 h. Hoechst 34580 can inhibit the aggregation of Aβ42 in a dose-dependent manner. And the half-maximal concentration (IC50) is examined. The IC50 is obtained by measuring the concentration of Hoechst 34580 while maintaining the Aβ42 concentration which gave 0.86±0.05 μM for Hoechst 34580[1].
References

[1]. Thai NQ, et al. Discovery of DNA dyes Hoechst 34580 and 33342 as good candidates for inhibiting amyloid beta formation: in silico and in vitro study. J Comput Aided Mol Des. 2016 Aug;30(8):639-50.

Molecular Formula C27H29N7
Molecular Weight 451.57
PSA 82.54000
LogP 5.86710
Storage condition 2-8℃