HOECHST 34580

Names

[ Name ]:
HOECHST 34580

[Synonym ]:
2'-(4-DIMETHYLAMINOPHENYL)-5-(4-METHYL-1-PIPERAZINYL)-2,5'-BI-BENZIMIDAZOLE
CS-1303
N,N-dimethyl-4-[5-(4-methyl-piperazin-1-yl)-1(3)H,1'(3')H-[2,5']bibenzoimidazolyl-2'-yl]-aniline
BBZ
4-dimethylamino-1-{5'-[5''-(4'''-methylpiperazin-1'''-yl)-1H-benzimidazol-2''-yl]-3H-benzimidazol-2'-yl}benzene
Proamine
para-dimethylamino-Hoechst
HOECHST 34580

Biological Activity

[Description]:

Hoechst 34580 is a cell-permeable fluorescent dye for staining DNA and nuclei.

[Related Catalog]:

Signaling Pathways >> Neuronal Signaling >> Amyloid-β

Dye Reagents

Research Areas >> Neurological Disease

[Target]

Amyloid-β[1]

[In Vitro]

Hoechst 34580 prefers to locate near hydrophobic regions with binding affinity with the inhibition constant IC50 of 0.86±0.05 μM for Hoechst 34580. Hoechst 34580 is a good candidate for treating the Alzheimer’s disease by inhibiting Aβ formation. 50 μM Aβ42 solutions co-incubated with 100, 25, 12.5, 3.125, 0.78, and 0.1, 0.01 μM Hoechst 34580 at 37 °C for 70 h. Hoechst 34580 can inhibit the aggregation of Aβ42 in a dose-dependent manner. And the half-maximal concentration (IC50) is examined. The IC50 is obtained by measuring the concentration of Hoechst 34580 while maintaining the Aβ42 concentration which gave 0.86±0.05 μM for Hoechst 34580[1].

[References]

[1]. Thai NQ, et al. Discovery of DNA dyes Hoechst 34580 and 33342 as good candidates for inhibiting amyloid beta formation: in silico and in vitro study. J Comput Aided Mol Des. 2016 Aug;30(8):639-50.

[Related Small Molecules]

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₇H₂₉N₇

[ Molecular Weight ]:
451.57

[ PSA ]:
82.54000

[ LogP ]:
5.86710

[ Storage condition ]:
2-8℃

HOECHST 34580

Names

Biological Activity

Chemical & Physical Properties

Related Compounds