Amyloid β-Protein (12-28)

Modify Date: 2024-01-02 17:39:54

Amyloid β-Protein (12-28) structure	Common Name	Amyloid β-Protein (12-28)
	CAS Number	107015-83-8	Molecular Weight	1955.18000
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₈₉H₁₃₅N₂₅O₂₅	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of Amyloid β-Protein (12-28)

β-amyloid (12-28) is a 17-aa peptide fragment, which can produce amyloid aggregates, used in the research of Alzheimer’sdisease.

Name	Amyloid β-Peptide (12-28) (human)
Synonym	More Synonyms

Description	β-amyloid (12-28) is a 17-aa peptide fragment, which can produce amyloid aggregates, used in the research of Alzheimer’sdisease.
Related Catalog	Signaling Pathways >> Neuronal Signaling >> Amyloid-β Research Areas >> Neurological Disease Peptides
Target	Amyloid-β[1]
In Vitro	β-amyloid (12-28) preared freshly in solution has no cytotoxicity, but aged β12-28 peptide (0.001-40 μM) reduces the viability of PC12 cells in a concentration dependent manner[1].
Cell Assay	PC12 pheochromocytoma cell lines are routinely cultured in Dulbecco's modified Eagle's medium containing 10% fetal bovine serum,5% horse serum, 1% glutamine and 1% penicillin/streptomycin. Exponentially growing cellsare plated at 30000 cells per well per 100 µL of fresh medium in 96-well tissue cultures plates. Toxicity assays are carried out by measurementof MTT reduction. Two days after plating PC12 pheochromocytoma cell lines are treated with different concentrations of aged β-amyloid (12-28). After 22 h, MTT (5 mg/mL) wasadded and incubation is continued for a further2 h. Cells are lysed and after 24 h at 37°C,colorimetric determination of MTT reduction is made at 550 nm. Positive controls consist of cells in culture medium. Assay values obtained with these controls are taken as 100% viability[1].
References	[1]. Rabanal F, et al. Structural, kinetic and cytotoxicity aspects of 12-28 beta-amyloid protein fragment: a reappraisal. J Pept Sci. 2002 Oct;8(10):578-88.

Molecular Formula	C₈₉H₁₃₅N₂₅O₂₅
Molecular Weight	1955.18000
Exact Mass	1954.01000
PSA	819.33000
LogP	2.72410
Storage condition	−20°C

WGK Germany	3

MFCD00133075

vhhqklvffaedvgsnk

sp17

amyloid b-protein fragment 12-28

m.w. 1955.20 c89h135n25o25

β-amyloid (12-28)

Zhejiang Hangyu API Co., Ltd
China
Product Name: Amyloid β-Protein (12-28)/β-Amyloid (12-28)
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