Name | 7-Bromo-N,N-dimethyl-9H-fluoren-2-amine |
---|---|
Synonyms | K 01-162 |
Description | K 01-162 (K162) binds and destabilizes AβO (β-amyloid), with an EC50 of 80 nM. IC50 value: 80 nM (EC50)Target: Amyloid-βin vitro: The active drug candidate K162 (EC50 = 0.080 μM), stabilizes hydrophobic core I of Aβ42 peptide (residues 17-21) to its α-helical conformation by interacting specifically in this region. [1] K01-162 shows full MC65 protection at 125 nM, an EC50 of 80 nM, and no cytotoxicity up to 50 μM. [2]in vivo:K01-162 can reduce the brain amyloid burden that exists in both fibrillar and RIPA-soluble, non-fibrillar forms.[2] |
---|---|
Related Catalog | |
References |
Molecular Formula | C15H14BrN |
---|---|
Molecular Weight | 288.18200 |
Exact Mass | 287.03100 |
PSA | 3.24000 |
LogP | 4.08630 |
Storage condition | 2-8℃ |