Bis-PEG2-acid

Modify Date: 2023-09-08 02:52:00

Bis-PEG2-acid Structure
Bis-PEG2-acid structure
Common Name Bis-PEG2-acid
CAS Number 19364-66-0 Molecular Weight 206.19300
Density N/A Boiling Point N/A
Molecular Formula C8H14O6 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of Bis-PEG2-acid


Bis-PEG2-acid is a PEG-based PROTAC linker can be used in the synthesis of PROTACs[1].

 Names

Name 3,3'-[ethane-1,2-diylbis(oxy)]dipropanoic acid
Synonym More Synonyms

 Bis-PEG2-acid Biological Activity

Description Bis-PEG2-acid is a PEG-based PROTAC linker can be used in the synthesis of PROTACs[1].
Related Catalog
Target

PEGs

In Vitro PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
References

[1]. Zhao Q, et al. Discovery of SIAIS178 as an Effective BCR-ABL Degrader by Recruiting Von Hippel-Lindau (VHL) E3 Ubiquitin Ligase. J Med Chem. 2019 Oct 24;62(20):9281-9298.

 Chemical & Physical Properties

Molecular Formula C8H14O6
Molecular Weight 206.19300
Exact Mass 206.07900
PSA 93.06000
Storage condition -20°C

 Synonyms

3,6-dioxaoctanedioic acid