19364-66-0

19364-66-0 structure

Name: Bis-PEG2-acid
Chemical Name: 3,3'-[ethane-1,2-diylbis(oxy)]dipropanoic acid
CAS Number: 19364-66-0
Molecular Formula: C₈H₁₄O₆
Molecular Weight: 206.19300
Catalog: Signaling Pathways PROTAC PROTAC Linker
Create Date: 2016-06-06 02:54:05
Modify Date: 2023-09-08 02:52:00
Bis-PEG2-acid is a PEG-based PROTAC linker can be used in the synthesis of PROTACs[1].

Name	3,3'-[ethane-1,2-diylbis(oxy)]dipropanoic acid
Synonyms	3,6-dioxaoctanedioic acid

Description	Bis-PEG2-acid is a PEG-based PROTAC linker can be used in the synthesis of PROTACs[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> PROTAC >> PROTAC Linker
Target	PEGs
In Vitro	PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
References	[1]. Zhao Q, et al. Discovery of SIAIS178 as an Effective BCR-ABL Degrader by Recruiting Von Hippel-Lindau (VHL) E3 Ubiquitin Ligase. J Med Chem. 2019 Oct 24;62(20):9281-9298.