Amino-PEG12-alcohol

Modify Date: 2024-01-02 11:46:53

Amino-PEG12-alcohol Structure
Amino-PEG12-alcohol structure
Common Name Amino-PEG12-alcohol
CAS Number 1345681-71-1 Molecular Weight 545.661
Density 1.1±0.1 g/cm3 Boiling Point 596.5±45.0 °C at 760 mmHg
Molecular Formula C24H51NO12 Melting Point N/A
MSDS N/A Flash Point 314.6±28.7 °C

 Use of Amino-PEG12-alcohol


Amino-PEG12-alcohol is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

 Names

Name H2N-PEG12-OH
Synonym More Synonyms

 Amino-PEG12-alcohol Biological Activity

Description Amino-PEG12-alcohol is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Related Catalog
Target

PEGs

In Vitro PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

 Chemical & Physical Properties

Density 1.1±0.1 g/cm3
Boiling Point 596.5±45.0 °C at 760 mmHg
Molecular Formula C24H51NO12
Molecular Weight 545.661
Flash Point 314.6±28.7 °C
Exact Mass 545.341125
LogP -4.95
Vapour Pressure 0.0±3.8 mmHg at 25°C
Index of Refraction 1.467

 Synonyms

35-Amino-3,6,9,12,15,18,21,24,27,30,33-undecaoxapentatriacontan-1-ol
3,6,9,12,15,18,21,24,27,30,33-Undecaoxapentatriacontan-1-ol, 35-amino-
Amino-dPEG(R)12-OH
MFCD11041097