1383814-00-3

1383814-00-3 structure
1383814-00-3 structure
  • Name: Amino-PEG12-Boc
  • Chemical Name: H2N-PEG12-tBu
  • CAS Number: 1383814-00-3
  • Molecular Formula: C31H63NO14
  • Molecular Weight: 673.830
  • Catalog: Signaling Pathways PROTAC PROTAC Linker
  • Create Date: 2018-06-11 10:14:26
  • Modify Date: 2024-01-04 17:02:31
  • Amino-PEG12-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

Name H2N-PEG12-tBu
Synonyms MFCD11041147
3,6,9,12,15,18,21,24,27,30,33,36-Dodecaoxanonatriacontan-39-oic acid, 1-amino-, 1,1-dimethylethyl ester
2-Methyl-2-propanyl 1-amino-3,6,9,12,15,18,21,24,27,30,33,36-dodecaoxanonatriacontan-39-oate
Description Amino-PEG12-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Related Catalog
Target

PEGs

Alkyl/ether

In Vitro PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

Density 1.1±0.1 g/cm3
Boiling Point 665.0±50.0 °C at 760 mmHg
Molecular Formula C31H63NO14
Molecular Weight 673.830
Flash Point 59.5±26.4 °C
Exact Mass 673.424866
LogP -3.10
Vapour Pressure 0.0±2.0 mmHg at 25°C
Index of Refraction 1.463