34188-11-9

34188-11-9 structure

Name: NH2-PEG5-OH
Chemical Name: 14-Amino-3,6,9,12-tetraoxatetradecan-1-ol
CAS Number: 34188-11-9
Molecular Formula: C₁₀H₂₃NO₅
Molecular Weight: 237.293
Catalog: Signaling Pathways Antibody-drug Conjugate ADC Linker
Create Date: 2018-06-26 11:38:08
Modify Date: 2024-01-03 18:01:01
NH2-PEG5-OH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. NH2-PEG5-OH is also a non-cleavable 5 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[2].

Name	14-Amino-3,6,9,12-tetraoxatetradecan-1-ol
Synonyms	14-Amino-3,6,9,12-tetraoxatetradecan-1-ol MFCD28950782 3,6,9,12-Tetraoxatetradecan-1-ol, 14-amino-

Description	NH2-PEG5-OH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. NH2-PEG5-OH is also a non-cleavable 5 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[2].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Antibody-drug Conjugate >> ADC Linker Signaling Pathways >> PROTAC >> PROTAC Linker
Target	PEGs Non-cleavable
In Vitro	PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1]. ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[2].
References	[1]. Nathanael Gray, et al. Bifunctional molecules for degradation of egfr and methods of use. WO2017185036A1. [2]. Nianhe Han, et al. Derivatives of dolastatin 10 and uses thereof. WO2016192527A1.