302331-20-0

302331-20-0 structure

Name: Boc-N-PEG2-Ms
Chemical Name: 2-(2-tert-butoxycarbonylaminoethoxy)ethanol methanesulfonic ester
CAS Number: 302331-20-0
Molecular Formula: C₁₀H₂₁NO₆S
Molecular Weight: 283.34200
Catalog: Signaling Pathways PROTAC PROTAC Linker
Create Date: 2016-02-01 12:26:45
Modify Date: 2024-01-04 10:32:43
Boc-N-PEG2-Ms is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

Name	2-(2-tert-butoxycarbonylaminoethoxy)ethanol methanesulfonic ester
Synonyms	2-[2-(tert-Butoxycarbonylamino)ethoxy]ethyl methanesulfonate 1-(2-(tert-butyloxycarbonylamino)ethoxy)-2-sulfonylethane 2-(2-(tert-butoxycarbonylamino)ethoxy)ethyl methanesulfonate 2-[2-(tert-butoxycarbonylamino)ethoxy]ethyl methanesulfonate 2-(2-((tert-butoxycarbonyl)amino)ethoxy)ethyl methanesulfonate 2-{2-[(tert-butoxycarbonyl)amino]ethoxy}ethyl methanesulfonate

Description	Boc-N-PEG2-Ms is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> PROTAC >> PROTAC Linker
Target	PEGs Alkyl/ether
In Vitro	PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References	[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562