1427004-19-0
1427004-19-0 structure
- Name: DBCO-PEG4-NHS ester
- Chemical Name: 4-(11,12-Didehydrodibenzo[b,f]azocin-5(6H)-yl)-N-{15-[(2,5-dioxo-1-pyrrolidinyl)oxy]-15-oxo-3,6,9,12-tetraoxapentadec-1-yl}-4-oxobutanamide
- CAS Number: 1427004-19-0
- Molecular Formula: C34H39N3O10
- Molecular Weight: 649.688
- Catalog: Signaling Pathways PROTAC PROTAC Linker
- Create Date: 2018-06-07 11:14:07
- Modify Date: 2025-08-25 19:43:31
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DBCO-PEG4-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
| Name | 4-(11,12-Didehydrodibenzo[b,f]azocin-5(6H)-yl)-N-{15-[(2,5-dioxo-1-pyrrolidinyl)oxy]-15-oxo-3,6,9,12-tetraoxapentadec-1-yl}-4-oxobutanamide |
|---|---|
| Synonyms |
Dibenz[b,f]azocine-5(6H)-butanamide, 11,12-didehydro-N-[15-[(2,5-dioxo-1-pyrrolidinyl)oxy]-15-oxo-3,6,9,12-tetraoxapentadec-1-yl]-γ-oxo-
4-(11,12-Didehydrodibenzo[b,f]azocin-5(6H)-yl)-N-{15-[(2,5-dioxo-1-pyrrolidinyl)oxy]-15-oxo-3,6,9,12-tetraoxapentadec-1-yl}-4-oxobutanamide |
| Description | DBCO-PEG4-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. |
|---|---|
| Related Catalog | |
| Target |
PEGs |
| In Vitro | PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1]. |
| References |
| Density | 1.3±0.1 g/cm3 |
|---|---|
| Molecular Formula | C34H39N3O10 |
| Molecular Weight | 649.688 |
| Exact Mass | 649.263550 |
| LogP | 0.56 |
| Index of Refraction | 1.608 |
| Storage condition | -20°C |