Propargyl-PEG1-acrylate

Modify Date: 2024-01-09 18:57:20

Propargyl-PEG1-acrylate Structure
Propargyl-PEG1-acrylate structure
Common Name Propargyl-PEG1-acrylate
CAS Number 52436-42-7 Molecular Weight 154.163
Density 1.0±0.1 g/cm3 Boiling Point 214.9±15.0 °C at 760 mmHg
Molecular Formula C8H10O3 Melting Point N/A
MSDS N/A Flash Point 81.7±15.0 °C

 Use of Propargyl-PEG1-acrylate


Propargyl-PEG1-acrylate is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

 Names

Name Propargyl-PEG2- acrylate
Synonym More Synonyms

 Propargyl-PEG1-acrylate Biological Activity

Description Propargyl-PEG1-acrylate is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Related Catalog
Target

PEGs

Alkyl/ether

In Vitro PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

 Chemical & Physical Properties

Density 1.0±0.1 g/cm3
Boiling Point 214.9±15.0 °C at 760 mmHg
Molecular Formula C8H10O3
Molecular Weight 154.163
Flash Point 81.7±15.0 °C
Exact Mass 154.062988
LogP 1.04
Vapour Pressure 0.2±0.4 mmHg at 25°C
Index of Refraction 1.451

 Synonyms

PROPARGYL-PEG2-AC
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