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85141-94-2

85141-94-2 structure
85141-94-2 structure
  • Name: Br-PEG4-OH
  • Chemical Name: 2-(2-(2-(2-bromoethoxy)ethoxy)-ethoxy)ethanol
  • CAS Number: 85141-94-2
  • Molecular Formula: C8H17BrO4
  • Molecular Weight: 257.12200
  • Catalog: Signaling Pathways PROTAC PROTAC Linker
  • Create Date: 2017-12-09 08:24:58
  • Modify Date: 2024-01-03 11:04:05
  • Br-PEG4-OH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

Name 2-(2-(2-(2-bromoethoxy)ethoxy)-ethoxy)ethanol
Synonyms 12-bromo-3,6,9,12-tetraoxadodecan-1-ol
2-[2-[2-(2-Bromoethoxy)ethoxy]ethoxy]-ethanol
Description Br-PEG4-OH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Related Catalog
Target

PEGs

In Vitro PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

Molecular Formula C8H17BrO4
Molecular Weight 257.12200
Exact Mass 256.03100
PSA 47.92000
LogP 0.42340
Hazard Codes Xi
Precursor  0

DownStream  1