PROTAC Linker

Total: 1884
Updated: 2019-06-28 15:55:20
The PROTAC linker connects two moieties: a small peptide residue for E3 ubiquitin ligase recognition,and a ligand that can be recognized by a targeted protein. Unlike the small molecule ligands, the length of the linker has been randomly selected for PROTACs, varying from 12-carbon to over 20-carbon in length. An optimal linker will allow for maximal interaction between the two moieties (target protein and E3 ligase) resulting in efficient ubiquitination of the target protein and its ultimate degradation.
The PROTAC linker connects two moieties: a small peptide residue for E3 ubiquitin ligase recognition,and a ligand that can be recognized by a targeted protein. Unlike the small molecule ligands, the length of the linker has been randomly selected for PROTACs, varying from 12-carbon to over 20-carbon in length. An optimal linker will allow for maximal interaction between the two moieties (target protein and E3 ligase) resulting in efficient ubiquitination of the target protein and its ultimate degradation.
The PROTAC linker connects two moieties: a small peptide residue for E3 ubiquitin ligase recognition,and a ligand that can be recognized by a targeted protein. Unlike the small molecule ligands, the length of the linker has been randomly selected for PROTACs, varying from 12-carbon to over 20-carbon in length. An optimal linker will allow for maximal interaction between the two moieties (target protein and E3 ligase) resulting in efficient ubiquitination of the target protein and its ultimate degradation.
The PROTAC linker connects two moieties: a small peptide residue for E3 ubiquitin ligase recognition,and a ligand that can be recognized by a targeted protein. Unlike the small molecule ligands, the length of the linker has been randomly selected for PROTACs, varying from 12-carbon to over 20-carbon in length. An optimal linker will allow for maximal interaction between the two moieties (target protein and E3 ligase) resulting in efficient ubiquitination of the target protein and its ultimate degradation.

Anti-infection >
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Antibody-drug Conjugate >
ADC Cytotoxin ADC Linker Drug-Linker Conjugates for ADC PROTAC-linker Conjugate for PAC
Apoptosis >
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Autophagy >
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Antifolate APC ATM/ATR Aurora Kinase Casein Kinase CDK Checkpoint Kinase (Chk) CRISPR/Cas9 Deubiquitinase DNA Alkylator/Crosslinker DNA-PK DNA/RNA Synthesis Eukaryotic Initiation Factor (eIF) G-quadruplex Haspin Kinase HDAC HSP IRE1 Kinesin LIM Kinase (LIMK) Microtubule/Tubulin Mps1 Nucleoside Antimetabolite/Analog p97 PAK PARP PERK Polo-like Kinase (PLK) PPAR RAD51 ROCK Sirtuin SRPK Telomerase TOPK Topoisomerase Wee1
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Aryl Hydrocarbon Receptor CCR Complement System COX CXCR FLAP Histamine Receptor IFNAR Interleukin Related IRAK MyD88 NO Synthase NOD-like Receptor (NLR) PD-1/PD-L1 PGE synthase Salt-inducible Kinase (SIK) SPHK STING Thrombopoietin Receptor Toll-like Receptor (TLR) Arginase
JAK/STAT Signaling >
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ERK JNK KLF MAP3K MAP4K MAPKAPK2 (MK2) MEK Mixed Lineage Kinase MNK p38 MAPK Raf Ribosomal S6 Kinase (RSK)
Membrane Transporter/Ion Channel >
ATP Synthase BCRP Calcium Channel CFTR Chloride Channel CRAC Channel CRM1 EAAT2 GABA Receptor GlyT HCN Channel iGluR Monoamine Transporter Monocarboxylate Transporter Na+/Ca2+ Exchanger Na+/HCO3- Cotransporter Na+/K+ ATPase nAChR NKCC P-glycoprotein P2X Receptor Potassium Channel Proton Pump SGLT Sodium Channel TRP Channel URAT1
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15-PGDH 5 alpha Reductase 5-Lipoxygenase Acetyl-CoA Carboxylase Acyltransferase Adenosine Deaminase Adenosine Kinase Aldehyde Dehydrogenase (ALDH) Aldose Reductase Aminopeptidase Angiotensin-converting Enzyme (ACE) ATGL ATP Citrate Lyase Carbonic Anhydrase Carboxypeptidase Cathepsin CETP COMT Cytochrome P450 Dipeptidyl Peptidase Dopamine β-hydroxylase E1/E2/E3 Enzyme Elastase Enolase FAAH FABP Factor Xa Farnesyl Transferase Fatty Acid Synthase (FAS) FXR Glucokinase GSNOR Gutathione S-transferase HCV Protease Hexokinase HIF/HIF Prolyl-Hydroxylase HIV Integrase HIV Protease HMG-CoA Reductase (HMGCR) HSP Indoleamine 2,3-Dioxygenase (IDO) Isocitrate Dehydrogenase (IDH) Lactate Dehydrogenase LXR MAGL Mineralocorticoid Receptor Mitochondrial Metabolism MMP Nampt NEDD8-activating Enzyme Neprilysin PAI-1 PDHK PGC-1α Phosphatase Phosphodiesterase (PDE) Phospholipase Procollagen C Proteinase Proteasome Pyruvate Kinase RAR/RXR Renin ROR Ser/Thr Protease SGK Stearoyl-CoA Desaturase (SCD) Thrombin Tryptophan Hydroxylase Tyrosinase Xanthine Oxidase
Neuronal Signaling >
5-HT Receptor AChE Adenosine Kinase Amyloid-β Beta-secretase CaMK CGRP Receptor COMT Dopamine Receptor Dopamine Transporter FAAH GABA Receptor GlyT iGluR Imidazoline Receptor mAChR Melatonin Receptor Monoamine Oxidase nAChR Neurokinin Receptor Opioid Receptor Serotonin Transporter γ-secretase
NF-κB >
NF-κB IKK Keap1-Nrf2 MALT1
PI3K/Akt/mTOR >
Akt AMPK ATM/ATR DNA-PK GSK-3 MELK mTOR PDK-1 PI3K PI4K PIKfyve PTEN
PROTAC >
PROTAC E3 Ligase Ligand-Linker Conjugate Ligand for E3 Ligase PROTAC Linker PROTAC-linker Conjugate for PAC
Protein Tyrosine Kinase/RTK >
Ack1 ALK Bcr-Abl BMX Kinase Btk c-Fms c-Kit c-Met/HGFR Discoidin Domain Receptor DYRK EGFR Ephrin Receptor FAK FGFR FLT3 IGF-1R Insulin Receptor IRAK Itk PDGFR PKA Pyk2 ROS Src Syk TAM Receptor Trk Receptor VEGFR
Stem Cell/Wnt >
Casein Kinase ERK Gli GSK-3 Hedgehog Hippo (MST) JAK Notch Oct3/4 PKA Porcupine ROCK sFRP-1 Smo STAT TGF-beta/Smad Wnt YAP β-catenin γ-secretase
TGF-beta/Smad >
TGF-beta/Smad PKC ROCK TGF-β Receptor
Vitamin D Related >
VD/VDR
Others >
Androgen Receptor Aromatase Estrogen Receptor/ERR Progesterone Receptor Thyroid Hormone Receptor Others
Others
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Acids and Aldehydes

1-tert-Butyl 18-(2,5-dioxopyrrolidin-1-yl) octadecanedioate

Boc-C16-NHS ester is an alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs[1].

  • CAS Number: 843666-34-2
  • MF: C26H45NO6
  • MW: 467.64
  • Catalog: PROTAC Linker
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A
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Boc-NHCH2CH2-PEG1-azide

Boc-NHCH2CH2-PEG1-azide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

  • CAS Number: 176220-30-7
  • MF: C9H18N4O3
  • MW: 230.26
  • Catalog: PROTAC Linker
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A
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N-Me-N-bis(PEG2-propargyl)

N-Me-N-bis(PEG2-propargyl) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

  • CAS Number: 1835759-84-6
  • MF: C15H25NO4
  • MW: 283.36
  • Catalog: PROTAC Linker
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A
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Folate-PEG2-amine

Folate-PEG2-amine is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

  • CAS Number: 1099829-15-8
  • MF: C25H33N9O7
  • MW: 571.59
  • Catalog: PROTAC Linker
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A
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Boc-NH-PEG10-CH2CH2NH2

Boc-NH-PEG10-CH2CH2NH2 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

  • CAS Number: 1347704-59-9
  • MF: C27H56N2O12
  • MW: 600.74
  • Catalog: PROTAC Linker
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A
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PROTAC Linker 2

PROTAC Linker 2 is a PROTAC linker utilized to connect the respective tyrosine kinase inhibitor (TKI) to the E3 recruiting ligand.

  • CAS Number: 1835705-52-6
  • MF: C21H41ClO4
  • MW: 393
  • Catalog: PROTAC Linker
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A
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t-Butoxycarbonyl-PEG4-sulfonic acid

Boc-PEG4-sulfonic acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

  • CAS Number: 1817735-26-4
  • MF: C15H30O9S
  • MW: 386.46
  • Catalog: PROTAC Linker
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A
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nonaethylene glycol

Nonaethylene glycol is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

  • CAS Number: 3386-18-3
  • MF: C18H38O10
  • MW: 414.488
  • Catalog: PROTAC Linker
  • Density: 1.1±0.1 g/cm3
  • Boiling Point: 506.2±45.0 °C at 760 mmHg
  • Melting Point: N/A
  • Flash Point: 260.0±28.7 °C
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[10-(Diethoxy-phosphoryl)-decyl]-phosphonic acid

[10-(Diethoxy-phosphoryl)-decyl]-phosphonic acid is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1].

  • CAS Number: 1446282-24-1
  • MF: C14H32O6P2
  • MW: 358.35
  • Catalog: PROTAC Linker
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A
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Propargyl-PEG3-alcohol

Propargyl-PEG3-alcohol is a PEG-based PROTAC linker can be used in the synthesis of PROTACs[1].

  • CAS Number: 208827-90-1
  • MF: C9H16O4
  • MW: 188.22100
  • Catalog: PROTAC Linker
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A
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Azido-PEG8-CH2CO2-PFP

Azido-PEG8-CH2COO-PFP is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

  • CAS Number: 2182601-80-3
  • MF: C24H34F5N3O10
  • MW: 619.53
  • Catalog: PROTAC Linker
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A
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CHO-CH2-PEG1-CH2-Boc

CHO-CH2-PEG1-CH2-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

  • CAS Number: 2230956-95-1
  • MF: C10H18O5
  • MW: 218.25
  • Catalog: PROTAC Linker
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A
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Boc-NH-PPG2

Boc-NH-PPG2 is an alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs[1].

  • CAS Number: 1312905-31-9
  • MF: C11H23NO4
  • MW: 233.30
  • Catalog: PROTAC Linker
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A
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Mal-PEG8-t-butyl ester

Mal-PEG8-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

  • CAS Number: 2055048-43-4
  • MF: C27H47NO12
  • MW: 577.66
  • Catalog: PROTAC Linker
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A
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Propargyl-PEG12-bromide

Propargyl-PEG12-bromide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

  • CAS Number: 2410937-34-5
  • MF: C29H55BrO13
  • MW: 691.64
  • Catalog: PROTAC Linker
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A
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Biotin-PEG4-Hydrazide

Biotin-PEG4-hydrazide is a biotin-labeled, PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

  • CAS Number: 756525-97-0
  • MF: C21H39N5O7S
  • MW: 505.63
  • Catalog: PROTAC Linker
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A
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Benzyl-PEG2-Tos

Benzyl-PEG2-Tos is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

  • CAS Number: 98627-22-6
  • MF: C18H22O5S
  • MW: 350.429
  • Catalog: PROTAC Linker
  • Density: 1.2±0.1 g/cm3
  • Boiling Point: 487.4±35.0 °C at 760 mmHg
  • Melting Point: N/A
  • Flash Point: 248.6±25.9 °C
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Methyl acetate-PEG1

Methyl acetate-PEG1 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

  • CAS Number: 58349-37-4
  • MF: C5H10O4
  • MW: 134.13
  • Catalog: PROTAC Linker
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A
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Bromo-PEG5-alcohol

Bromo-PEG5-alcohol is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

  • CAS Number: 957205-14-0
  • MF: C10H21BrO5
  • MW: 301.17500
  • Catalog: PROTAC Linker
  • Density: 1.3±0.1 g/cm3
  • Boiling Point: 364.6±32.0 °C at 760 mmHg
  • Melting Point: N/A
  • Flash Point: 174.3±25.1 °C
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Acid-PEG4-C2-Boc

Acid-PEG4-C2-Boc is a PEG- and Alkyl/ether-based PROTAC linker can be used in the synthesis of PROTACs for the inhibition of mTOR[1].

  • CAS Number: 1835759-85-7
  • MF: C16H30O8
  • MW: 406.511
  • Catalog: PROTAC Linker
  • Density: 1.0±0.1 g/cm3
  • Boiling Point: 452.9±35.0 °C at 760 mmHg
  • Melting Point: N/A
  • Flash Point: 191.1±26.0 °C
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Boc-C1-PEG2-C4-Cl

PROTAC Linker 1 is a PROTAC linker utilized to connect the respective tyrosine kinase inhibitor (TKI) to the E3 recruiting ligand.

  • CAS Number: 1835705-53-7
  • MF: C14H27ClO4
  • MW: 294.81
  • Catalog: PROTAC Linker
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A
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Boc-NH-PEG6-CH2COOH

Boc-NH-PEG6-CH2COOH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

  • CAS Number: 391684-36-9
  • MF: C19H37NO10
  • MW: 439.498
  • Catalog: PROTAC Linker
  • Density: 1.1±0.1 g/cm3
  • Boiling Point: 557.7±50.0 °C at 760 mmHg
  • Melting Point: N/A
  • Flash Point: 291.1±30.1 °C
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Bromo-PEG5-C2-acid

Bromo-PEG5-C2-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

  • CAS Number: 1817735-27-5
  • MF: C13H25BrO7
  • MW: 373.24
  • Catalog: PROTAC Linker
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A
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endo-BCN-PEG2-C2-NHS ester

endo-BCN-PEG2-C2-NHS ester is a PEG-based PROTAC linker can be used in the synthesis of PROTACs.

  • CAS Number: 2243565-12-8
  • MF: C22H30N2O8
  • MW: 450.48
  • Catalog: PROTAC Linker
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A
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Thiol-PEG6-alcohol

Thiol-PEG6-alcohol is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

  • CAS Number: 194425-46-2
  • MF: C12H26O6S
  • MW: 298.39600
  • Catalog: PROTAC Linker
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A
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diethyl 8-bromooctylphosphonate

Diethyl 8-bromooctylphosphonate is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1].

  • CAS Number: 124939-70-4
  • MF: C12H26BrO3P
  • MW: 329.21
  • Catalog: PROTAC Linker
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A
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Biotin-PEG11-CH2CH2N3

Biotin-PEG11-azide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

  • CAS Number: 2276672-04-7
  • MF: C34H64N6O13S
  • MW: 796.97
  • Catalog: PROTAC Linker
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A
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N-Me-N-(PEG2-OH)2

N-Me-N-bis-PEG3 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

  • CAS Number: 342818-95-5
  • MF: C13H29NO6
  • MW: 295.37
  • Catalog: PROTAC Linker
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A
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5-Ethynyl-2'-deoxyuridine

5-Ethynyl-2'-deoxyuridine is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1].

  • CAS Number: 61135-33-9
  • MF: C11H12N2O5
  • MW: 252.22300
  • Catalog: PROTAC Linker
  • Density: 1.55g/cm3
  • Boiling Point: N/A
  • Melting Point: 199 °C
  • Flash Point: N/A
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HO-PEG15-OH

HO-PEG15-OH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

  • CAS Number: 28821-35-4
  • MF: C30H62O16
  • MW: 678.80400
  • Catalog: PROTAC Linker
  • Density: 1.116g/cm3
  • Boiling Point: 687.9ºC at 760mmHg
  • Melting Point: N/A
  • Flash Point: 369.8ºC
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