Thiol-PEG6-alcohol

Modify Date: 2024-01-16 13:24:19

Thiol-PEG6-alcohol Structure
Thiol-PEG6-alcohol structure
Common Name Thiol-PEG6-alcohol
CAS Number 194425-46-2 Molecular Weight 298.39600
Density N/A Boiling Point N/A
Molecular Formula C12H26O6S Melting Point N/A
MSDS N/A Flash Point N/A

 Use of Thiol-PEG6-alcohol


Thiol-PEG6-alcohol is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

 Names

Name 2-[2-[2-[2-[2-(2-sulfanylethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethanol
Synonym More Synonyms

 Thiol-PEG6-alcohol Biological Activity

Description Thiol-PEG6-alcohol is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Related Catalog
Target

PEGs

In Vitro PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562.

 Chemical & Physical Properties

Molecular Formula C12H26O6S
Molecular Weight 298.39600
Exact Mass 298.14500
PSA 105.18000

 Synthetic Route

~51%

Thiol-PEG6-alcohol Structure

Thiol-PEG6-alcohol

CAS#:194425-46-2

Literature: Boden, Neville; Bushby, Richard J.; Clarkson, Steven; Evans, Stephen D.; Knowles, Peter F.; Marsh, Andrew Tetrahedron, 1997 , vol. 53, # 31 p. 10939 - 10952

~%

Thiol-PEG6-alcohol Structure

Thiol-PEG6-alcohol

CAS#:194425-46-2

Literature: Boden, Neville; Bushby, Richard J.; Clarkson, Steven; Evans, Stephen D.; Knowles, Peter F.; Marsh, Andrew Tetrahedron, 1997 , vol. 53, # 31 p. 10939 - 10952

~%

Thiol-PEG6-alcohol Structure

Thiol-PEG6-alcohol

CAS#:194425-46-2

Literature: Boden, Neville; Bushby, Richard J.; Clarkson, Steven; Evans, Stephen D.; Knowles, Peter F.; Marsh, Andrew Tetrahedron, 1997 , vol. 53, # 31 p. 10939 - 10952

 Synonyms

mercaptohexaethylene glycol
3,6,9,12,15-Pentaoxaheptadecan-1-ol,17-mercapto
17-mercapto-3,6,9,12,15-pentaoxaheptadecanol