Thiol-PEG6-acid

Modify Date: 2024-02-29 19:16:12

Thiol-PEG6-acid Structure
Thiol-PEG6-acid structure
Common Name Thiol-PEG6-acid
CAS Number 1347750-77-9 Molecular Weight 370.459
Density 1.1±0.1 g/cm3 Boiling Point 495.1±45.0 °C at 760 mmHg
Molecular Formula C15H30O8S Melting Point N/A
MSDS N/A Flash Point 253.2±28.7 °C

 Use of Thiol-PEG6-acid


Thiol-PEG6-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

 Names

Name 1-Sulfanyl-3,6,9,12,15,18-hexaoxahenicosan-21-oic acid
Synonym More Synonyms

 Thiol-PEG6-acid Biological Activity

Description Thiol-PEG6-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Related Catalog
Target

PEGs

In Vitro PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562.

 Chemical & Physical Properties

Density 1.1±0.1 g/cm3
Boiling Point 495.1±45.0 °C at 760 mmHg
Molecular Formula C15H30O8S
Molecular Weight 370.459
Flash Point 253.2±28.7 °C
Exact Mass 370.166138
LogP -1.37
Vapour Pressure 0.0±2.7 mmHg at 25°C
Index of Refraction 1.478

 Synonyms

3,6,9,12,15,18-Hexaoxaheneicosan-21-oic acid, 1-mercapto-
MFCD26127814
1-Sulfanyl-3,6,9,12,15,18-hexaoxahenicosan-21-oic acid
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