194425-46-2
194425-46-2 structure
- Name: Thiol-PEG6-alcohol
- Chemical Name: 2-[2-[2-[2-[2-(2-sulfanylethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethanol
- CAS Number: 194425-46-2
- Molecular Formula: C12H26O6S
- Molecular Weight: 298.39600
- Catalog: Signaling Pathways PROTAC PROTAC Linker
- Create Date: 2017-01-14 10:29:56
- Modify Date: 2024-01-16 13:24:19
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Thiol-PEG6-alcohol is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
| Name | 2-[2-[2-[2-[2-(2-sulfanylethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethanol |
|---|---|
| Synonyms |
mercaptohexaethylene glycol
3,6,9,12,15-Pentaoxaheptadecan-1-ol,17-mercapto 17-mercapto-3,6,9,12,15-pentaoxaheptadecanol |
| Description | Thiol-PEG6-alcohol is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. |
|---|---|
| Related Catalog | |
| Target |
PEGs |
| In Vitro | PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1]. |
| References |
| Molecular Formula | C12H26O6S |
|---|---|
| Molecular Weight | 298.39600 |
| Exact Mass | 298.14500 |
| PSA | 105.18000 |
|
~51%
194425-46-2 |
| Literature: Boden, Neville; Bushby, Richard J.; Clarkson, Steven; Evans, Stephen D.; Knowles, Peter F.; Marsh, Andrew Tetrahedron, 1997 , vol. 53, # 31 p. 10939 - 10952 |
|
~%
194425-46-2 |
| Literature: Boden, Neville; Bushby, Richard J.; Clarkson, Steven; Evans, Stephen D.; Knowles, Peter F.; Marsh, Andrew Tetrahedron, 1997 , vol. 53, # 31 p. 10939 - 10952 |
|
~%
194425-46-2 |
| Literature: Boden, Neville; Bushby, Richard J.; Clarkson, Steven; Evans, Stephen D.; Knowles, Peter F.; Marsh, Andrew Tetrahedron, 1997 , vol. 53, # 31 p. 10939 - 10952 |
