Propargyl-PEG6-alcohol

Modify Date: 2024-01-09 12:20:20

Propargyl-PEG6-alcohol Structure
Propargyl-PEG6-alcohol structure
Common Name Propargyl-PEG6-alcohol
CAS Number 944560-99-0 Molecular Weight 320.379
Density 1.1±0.1 g/cm3 Boiling Point 408.8±40.0 °C at 760 mmHg
Molecular Formula C15H28O7 Melting Point N/A
MSDS N/A Flash Point 201.1±27.3 °C

 Use of Propargyl-PEG6-alcohol


Propargyl-PEG6-alcohol is a PEG-based PROTAC linker can be used in the synthesis of PROTACs[1].

 Names

Name 3,6,9,12,15,18-Hexaoxahenicos-20-yn-1-ol
Synonym More Synonyms

 Propargyl-PEG6-alcohol Biological Activity

Description Propargyl-PEG6-alcohol is a PEG-based PROTAC linker can be used in the synthesis of PROTACs[1].
Related Catalog
Target

PEGs

In Vitro PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
References

[1]. Goswami LN, et al. Efficient synthesis of diverse heterobifunctionalized clickable oligo(ethylene glycol) linkers: potential applications in bioconjugation and targeted drug delivery. Org Biomol Chem. 2013 Feb 21;11(7):1116-26.

 Chemical & Physical Properties

Density 1.1±0.1 g/cm3
Boiling Point 408.8±40.0 °C at 760 mmHg
Molecular Formula C15H28O7
Molecular Weight 320.379
Flash Point 201.1±27.3 °C
Exact Mass 320.183502
LogP -2.04
Vapour Pressure 0.0±2.2 mmHg at 25°C
Index of Refraction 1.463

 Synonyms

3,6,9,12,15,18-Hexaoxahenicos-20-yn-1-ol
3,6,9,12,15,18-Hexaoxaheneicos-20-yn-1-ol