Shanghai Jizhi Biochemical Technology Co., Ltd
China
Product Name: 5-Ethynyl-2'-deoxyuridine
Price: ￥378.0/100mg ￥888.0/250mg ￥1888.0/1g
Purity: 98.0%
Stocking Period: Inquiry
Contact: Liu jia

DC Chemicals Limited
China
Product Name: EdU (ethynyldeoxyuridine)
Price: $Inquiry/100mg $Inquiry/250mg $Inquiry/500mg
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

Zhejiang Hangyu API Co., Ltd
China
Product Name: 5-Ethynyl-2'-deoxyuridine
Price: ￥Inquiry/1kg
Purity: 99.5%
Stocking Period: Inquiry
Contact: Vinnie

61135-33-9

61135-33-9 structure

61135-33-9 structure

Name: 5-Ethynyl-2'-deoxyuridine
Chemical Name: 5-Ethynyl-2′-deoxyuridine, (EdU)
CAS Number: 61135-33-9
Molecular Formula: C₁₁H₁₂N₂O₅
Molecular Weight: 252.22300
Catalog: Signaling Pathways PROTAC PROTAC Linker
Create Date: 2018-07-19 17:24:47
Modify Date: 2024-01-06 12:33:06
5-Ethynyl-2'-deoxyuridine is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1].

Name	5-Ethynyl-2′-deoxyuridine, (EdU)
Synonyms	5-ethynyl-1-[(2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidine-2,4-dione 5-Ethynyl-2'-deoxyuridine

Description	5-Ethynyl-2'-deoxyuridine is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> PROTAC >> PROTAC Linker
Target	Alkyl-Chain
In Vitro	PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References	[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

Density	1.55g/cm3
Melting Point	199 °C
Molecular Formula	C₁₁H₁₂N₂O₅
Molecular Weight	252.22300
Exact Mass	252.07500
PSA	104.55000
Index of Refraction	1.644

CHEMICAL IDENTIFICATION

RTECS NUMBER :: YU7510000

CHEMICAL NAME :: Uridine, 2'-deoxy-5-ethynyl-

CAS REGISTRY NUMBER :: 61135-33-9

LAST UPDATED :: 199612

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C11-H12-N2-O5

MOLECULAR WEIGHT :: 252.25

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

MUTATION DATA

TYPE OF TEST :: Sister chromatid exchange

TEST SYSTEM :: Human Lung

DOSE/DURATION :: 500 ug/L

REFERENCE :: MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 117,317,1983

Symbol	GHS08
Signal Word	Danger
Hazard Statements	H340-H361
Precautionary Statements	P201-P281-P308 + P313
Hazard Codes	Xi
RIDADR	NONH for all modes of transport

Precursor 8
54-42-2 69075-43-0 31356-86-2 149798-19-6
1066-54-2 78731-54-1 5168-36-5 151361-85-2
DownStream 5
15176-29-1 117626-80-9 55520-67-7 59090-41-4
596107-17-4