843666-34-2

843666-34-2 structure

843666-34-2 structure

Name: 1-tert-Butyl 18-(2,5-dioxopyrrolidin-1-yl) octadecanedioate
Chemical Name: Boc-C16-NHS ester
CAS Number: 843666-34-2
Molecular Formula: C₂₆H₄₅NO₆
Molecular Weight: 467.64
Catalog: Signaling Pathways PROTAC PROTAC Linker
Create Date: 2020-06-01 20:20:19
Modify Date: 2024-01-12 16:48:12
Boc-C16-NHS ester is an alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs[1].

Name	Boc-C16-NHS ester
Synonyms	MFCD29923003

Description	Boc-C16-NHS ester is an alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> PROTAC >> PROTAC Linker
Target	Alkyl/ether
In Vitro	PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References	[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

Molecular Formula	C₂₆H₄₅NO₆
Molecular Weight	467.64