GL Biochem (Shanghai) Ltd.
China
Product Name: L-alanine
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Shanghai Jizhi Biochemical Technology Co., Ltd
China
Product Name: L-alanine
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DC Chemicals Limited
China
Product Name: L-Alanine
Price: $280.0/20mg
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Nanjing Peptide Biotech Ltd
China
Product Name: H-Ala-OH
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Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: L-Alanine
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Purity: 98.0%
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56-41-7

56-41-7 structure

Name: L-alanine
Chemical Name: L-alanine
CAS Number: 56-41-7
Molecular Formula: C₃H₇NO₂
Molecular Weight: 89.093
Catalog: Organic raw materials Hydrocarbon compounds and their derivatives Hydrocarbon halide
Create Date: 2018-06-25 13:09:33
Modify Date: 2024-01-02 15:40:40
L-Alanine is a non-essential amino acid, involved in sugar and acid metabolism, increases immunity, and provides energy for muscle tissue, brain, and central nervous system.

Name	L-alanine
Synonyms	L-ARANINE MFCD00064410 Fmoc-L-Ala-OH H-L-ALA-OH H-ALA-OH L-ALA ALANINE ALA L-Alanine Alanin EINECS 200-273-8 Ritalanine L-alamine

Description	L-Alanine is a non-essential amino acid, involved in sugar and acid metabolism, increases immunity, and provides energy for muscle tissue, brain, and central nervous system.
Related Catalog	Research Areas >> Metabolic Disease Research Areas >> Neurological Disease Natural Products >> Others
Target	Human Endogenous Metabolite
In Vitro	The viability of both hiPSCs, 201B7 cells and ehiPSCs decrease with an increase in L-Alanine concentration, and reach 7.5±1.3% and 3.7±0.7% respectively at 1.2 M of L-Alanine. On the other hand, no decrease in the viability of hFBs and hSkMCs are observed. Although the viability of iCMs slightly decreases along with the increase of the L-Alanine concentration, viability of iCMs at 1.2 M concentration of L-Alanine, 49.4±6.9%, is significantly higher than that of undifferentiated iPSCs, 201B7 cells and ehiPSCs (p< 0.01). The viability of hiPSCs, 201B7 cells and ehiPSCs, drastically decrease even after 2 or 4 h treatment. In contrast, the viability of hFBs fails to decrease at 1, 2, and 4 h and shows a small decrease at 24 h treatment. The viability of 201B7 cells in suspension culture decreases to 11.8±6.0% following treatment with 1.2 M L-Alanine for 2 h, whereas that of hFBs is 72.9±14.2%[1].
Cell Assay	To investigate the selective removal of hiPSCs from differentiated cells by the high L-Alanine medium, two types of hiPSCs, 201B7 hiPSCs (201B7 cells) and an hiPSC line derived by episomal system (ehiPSCs) are used, along with normal human dermal fibroblasts (hFBs), human skeletal muscle cells (hSkMCs) and hiPSC-derived cardiomyocytes (iCMs) as differentiated cells. The cells are incubated in a medium supplemented with L-Alanine at various concentrations (0-1.2 M) or treatment times (1-24 h). The medium is replaced with a normal medium and the relative cell viability is measured after 24 h[1].
References	[1]. Nagashima T, et al. Selective Elimination of Human Induced Pluripotent Stem Cells Using Medium with High Concentration of L-Alanine. Sci Rep. 2018 Aug 20;8(1):12427.

Density	1.2±0.1 g/cm3
Boiling Point	212.9±23.0 °C at 760 mmHg
Melting Point	314.5 °C (dec.)(lit.)
Molecular Formula	C₃H₇NO₂
Molecular Weight	89.093
Flash Point	82.6±22.6 °C
Exact Mass	89.047676
PSA	63.32000
LogP	-0.68
Vapour Pressure	0.1±0.9 mmHg at 25°C
Index of Refraction	1.460
Water Solubility	166.5 g/L (25 ºC)

CHEMICAL IDENTIFICATION

RTECS NUMBER :: AY2990000

CHEMICAL NAME :: Alanine, L-

CAS REGISTRY NUMBER :: 56-41-7

LAST UPDATED :: 199701

DATA ITEMS CITED :: 4

MOLECULAR FORMULA :: C3-H7-N-O2

MOLECULAR WEIGHT :: 89.11

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

MUTATION DATA

TYPE OF TEST :: Sister chromatid exchange

TEST SYSTEM :: Human Lymphocyte

DOSE/DURATION :: 50 mg/L

REFERENCE :: MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 280,279,1992 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 81817 No. of Facilities: 290 (estimated) No. of Industries: 3 No. of Occupations: 3 No. of Employees: 2729 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 81817 No. of Facilities: 904 (estimated) No. of Industries: 2 No. of Occupations: 6 No. of Employees: 18364 (estimated) No. of Female Employees: 14698 (estimated)

Personal Protective Equipment	Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Hazard Codes	Xi: Irritant;
Risk Phrases	36/37/38
Safety Phrases	S24/25
RIDADR	NONH for all modes of transport
WGK Germany	3
RTECS	AY2990000
HS Code	2930901000

Precursor 7
100516-58-3 312-85-6 1142-20-7 136440-35-2
504-07-4 21028-15-9 5673-65-4
DownStream 10
108462-95-9 5625-46-7 3303-34-2 57105-39-2
42854-62-6 56255-31-3 328-42-7 32644-15-8
39825-33-7 56452-52-9

HS Code	2930901000

56-41-7	6898-94-8
25281-63-4	74280-71-0
62656-85-3	21764-56-7
65163-25-9	63546-27-0
65163-26-0	18806-29-6