|CAS Number||56-41-7||Molecular Weight||89.093|
|Density||1.2±0.1 g/cm3||Boiling Point||212.9±23.0 °C at 760 mmHg|
|Molecular Formula||C3H7NO2||Melting Point||314.5 °C (dec.)(lit.)|
|MSDS||Chinese USA||Flash Point||82.6±22.6 °C|
Use of L-alanine
L-Alanine is a non-essential amino acid, involved in sugar and acid metabolism, increases immunity, and provides energy for muscle tissue, brain, and central nervous system.
|Description||L-Alanine is a non-essential amino acid, involved in sugar and acid metabolism, increases immunity, and provides energy for muscle tissue, brain, and central nervous system.|
Human Endogenous Metabolite
|In Vitro||The viability of both hiPSCs, 201B7 cells and ehiPSCs decrease with an increase in L-Alanine concentration, and reach 7.5±1.3% and 3.7±0.7% respectively at 1.2 M of L-Alanine. On the other hand, no decrease in the viability of hFBs and hSkMCs are observed. Although the viability of iCMs slightly decreases along with the increase of the L-Alanine concentration, viability of iCMs at 1.2 M concentration of L-Alanine, 49.4±6.9%, is significantly higher than that of undifferentiated iPSCs, 201B7 cells and ehiPSCs (p< 0.01). The viability of hiPSCs, 201B7 cells and ehiPSCs, drastically decrease even after 2 or 4 h treatment. In contrast, the viability of hFBs fails to decrease at 1, 2, and 4 h and shows a small decrease at 24 h treatment. The viability of 201B7 cells in suspension culture decreases to 11.8±6.0% following treatment with 1.2 M L-Alanine for 2 h, whereas that of hFBs is 72.9±14.2%.|
H2O : 150 mg/mL (1683.69 mM; Need ultrasonic and warming)
|Cell Assay||To investigate the selective removal of hiPSCs from differentiated cells by the high L-Alanine medium, two types of hiPSCs, 201B7 hiPSCs (201B7 cells) and an hiPSC line derived by episomal system (ehiPSCs) are used, along with normal human dermal fibroblasts (hFBs), human skeletal muscle cells (hSkMCs) and hiPSC-derived cardiomyocytes (iCMs) as differentiated cells. The cells are incubated in a medium supplemented with L-Alanine at various concentrations (0-1.2 M) or treatment times (1-24 h). The medium is replaced with a normal medium and the relative cell viability is measured after 24 h.|
|Shipping||Room temperature in continental US; may vary elsewhere|
|Related Molecules||3-Methyladenine | Hydrocortisone | Acetylcysteine | Tretinoin | Melatonine | Prostaglandin E2 | Nicotinamide | Adenosine triphosphate | 4-Acetamidophenol | Prostaglandin E1 | Dehydroepiandrosterone | Corticosterone | Progesterone | Docosahexaenoic Acid | NAD+|
*The above documents are provided by Medchemexpress and are for scientific research only.
|Boiling Point||212.9±23.0 °C at 760 mmHg|
|Melting Point||314.5 °C (dec.)(lit.)|
|Flash Point||82.6±22.6 °C|
|Vapour Pressure||0.1±0.9 mmHg at 25°C|
|Index of Refraction||1.460|
|Water Solubility||166.5 g/L (25 ºC)|
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
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