Boc-C1-PEG2-C4-Cl

Modify Date: 2024-01-09 18:44:47

Boc-C1-PEG2-C4-Cl Structure
Boc-C1-PEG2-C4-Cl structure
Common Name Boc-C1-PEG2-C4-Cl
CAS Number 1835705-53-7 Molecular Weight 294.81
Density N/A Boiling Point N/A
Molecular Formula C14H27ClO4 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of Boc-C1-PEG2-C4-Cl


PROTAC Linker 1 is a PROTAC linker utilized to connect the respective tyrosine kinase inhibitor (TKI) to the E3 recruiting ligand.

 Names

Name PROTAC Linker 1

 Boc-C1-PEG2-C4-Cl Biological Activity

Description PROTAC Linker 1 is a PROTAC linker utilized to connect the respective tyrosine kinase inhibitor (TKI) to the E3 recruiting ligand.
Related Catalog
In Vitro PROTAC technology employs small molecules that recruit target proteins for ubiquitination and removal by the proteasome. The synthesis of PROTAC compounds that mediate the degradation of c-ABL and BCR-ABL by recruiting either Cereblon or Von Hippel Lindau E3 ligases is reported. PROTAC Linker 1 is designated as 6-2-2[1].
References

[1]. Lai AC, et al. Modular PROTAC Design for the Degradation of Oncogenic BCR-ABL. Angew Chem Int Ed Engl. 2016 Jan 11;55(2):807-10.

 Chemical & Physical Properties

Molecular Formula C14H27ClO4
Molecular Weight 294.81
Storage condition 2-8℃
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