Boc-C1-PEG2-C4-Cl

Names

[ Name ]:
Boc-C1-PEG2-C4-Cl

Biological Activity

[Description]:

PROTAC Linker 1 is a PROTAC linker utilized to connect the respective tyrosine kinase inhibitor (TKI) to the E3 recruiting ligand.

[Related Catalog]:

Signaling Pathways >> PROTAC >> PROTAC Linker

Research Areas >> Cancer

[In Vitro]

PROTAC technology employs small molecules that recruit target proteins for ubiquitination and removal by the proteasome. The synthesis of PROTAC compounds that mediate the degradation of c-ABL and BCR-ABL by recruiting either Cereblon or Von Hippel Lindau E3 ligases is reported. PROTAC Linker 1 is designated as 6-2-2[1].

[References]

[1]. Lai AC, et al. Modular PROTAC Design for the Degradation of Oncogenic BCR-ABL. Angew Chem Int Ed Engl. 2016 Jan 11;55(2):807-10.

[Related Small Molecules]

N33-TEG-COOH | Cl-C6-PEG4-O-CH2COOH | Protac linker 5 | PROTAC Linker 2

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₄H₂₇ClO₄

[ Molecular Weight ]:
294.81

[ Storage condition ]:
2-8℃

Related Compounds

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