The PROTAC linker connects two moieties: a small peptide residue for E3 ubiquitin ligase recognition,and a ligand that can be recognized by a targeted protein. Unlike the small molecule ligands, the length of the linker has been randomly selected for PROTACs, varying from 12-carbon to over 20-carbon in length. An optimal linker will allow for maximal interaction between the two moieties (target protein and E3 ligase) resulting in efficient ubiquitination of the target protein and its ultimate degradation.
The PROTAC linker connects two moieties: a small peptide residue for E3 ubiquitin ligase recognition,and a ligand that can be recognized by a targeted protein. Unlike the small molecule ligands, the length of the linker has been randomly selected for PROTACs, varying from 12-carbon to over 20-carbon in length. An optimal linker will allow for maximal interaction between the two moieties (target protein and E3 ligase) resulting in efficient ubiquitination of the target protein and its ultimate degradation.
The PROTAC linker connects two moieties: a small peptide residue for E3 ubiquitin ligase recognition,and a ligand that can be recognized by a targeted protein. Unlike the small molecule ligands, the length of the linker has been randomly selected for PROTACs, varying from 12-carbon to over 20-carbon in length. An optimal linker will allow for maximal interaction between the two moieties (target protein and E3 ligase) resulting in efficient ubiquitination of the target protein and its ultimate degradation.
The PROTAC linker connects two moieties: a small peptide residue for E3 ubiquitin ligase recognition,and a ligand that can be recognized by a targeted protein. Unlike the small molecule ligands, the length of the linker has been randomly selected for PROTACs, varying from 12-carbon to over 20-carbon in length. An optimal linker will allow for maximal interaction between the two moieties (target protein and E3 ligase) resulting in efficient ubiquitination of the target protein and its ultimate degradation.


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Amino-PEG4-C2-amine

Amino-PEG4-C2-amine is a PEG-based (4 units) PROTAC linker can be used in the synthesis of PROTACs.

  • CAS Number: 68960-97-4
  • MF: C10H24N2O4
  • MW: 236.30900
  • Catalog: PROTAC Linker
  • Density: N/A
  • Boiling Point: 139 °C/0.2 mmHg
  • Melting Point: N/A
  • Flash Point: 157 °C

Bis-propargyl-PEG3

Bis-propargyl-PEG3 is a PEG-based PROTAC linker used in the synthesis of PROTACs. Bis-propargyl-PEG3 is used in the synthesis of zinc-dipicolylamine (ZnDPA) complexes with antiplasmodial activity[1] [2].

  • CAS Number: 126422-58-0
  • MF: C12H18O4
  • MW: 226.26900
  • Catalog: PROTAC Linker
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A

Bis-dPEG13-PFP ester

Bis-PEG9-PFP ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

  • CAS Number: 1334170-00-1
  • MF: C34H40F10O13
  • MW: 846.657632
  • Catalog: PROTAC Linker
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A

Benzyl-PEG2-MS

Benzyl-PEG2-MS is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

  • CAS Number: 150272-33-6
  • MF: C12H18O5S
  • MW: 274.33
  • Catalog: PROTAC Linker
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A

4-Bromobutylphosphonic acid

4-Bromobutylphosphonic acid is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1].

  • CAS Number: 1190-14-3
  • MF: C4H10BrO3P
  • MW: 216.99800
  • Catalog: PROTAC Linker
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: 129 °C
  • Flash Point: N/A

t-Boc-Aminooxy-PEG4-NHS ester

t-Boc-Aminooxy-PEG4-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

  • CAS Number: 2401831-99-8
  • MF: C20H34N2O11
  • MW: 478.49
  • Catalog: PROTAC Linker
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A

N-methyl-N-(t-Boc)-PEG4-acid

N-Methyl-N-(t-Boc)-PEG4-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

  • CAS Number: 1260431-01-3
  • MF: C17H33NO8
  • MW: 379.446
  • Catalog: PROTAC Linker
  • Density: 1.1±0.1 g/cm3
  • Boiling Point: 488.2±45.0 °C at 760 mmHg
  • Melting Point: N/A
  • Flash Point: 249.1±28.7 °C

2-Bromo-22-dimethyl-acetamido-PEG3-acid

2-Bromo-22-dimethyl-acetamido-PEG3-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

  • CAS Number: 2279944-67-9
  • MF: C13H24BrNO6
  • MW: 370.24
  • Catalog: PROTAC Linker
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A

HS-PEG6-CH2CH2-Boc

HS-PEG6-CH2CH2-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

  • CAS Number: 1818294-40-4
  • MF: C19H38O8S
  • MW: 426.565
  • Catalog: PROTAC Linker
  • Density: 1.1±0.1 g/cm3
  • Boiling Point: 488.8±45.0 °C at 760 mmHg
  • Melting Point: N/A
  • Flash Point: 337.6±16.6 °C

Phthalamide-PEG3-azide

Phthalamide-PEG3-azide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

  • CAS Number: 134179-44-5
  • MF: C16H20N4O5
  • MW: 348.35400
  • Catalog: PROTAC Linker
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A

TCO-C3-PEG3-C3-amine

TCO-C3-PEG3-C3-amine is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

  • CAS Number: 2028288-77-7
  • MF: C19H36N2O5
  • MW: 372.50
  • Catalog: PROTAC Linker
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A

2,5,8,11,14,17,20-Heptaoxadocosan-22-oic acid

m-PEG6-O-CH2COOH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

  • CAS Number: 75427-75-7
  • MF: C15H30O9
  • MW: 354.39
  • Catalog: PROTAC Linker
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A

Bis-propargyl-PEG8

Bis-propargyl-PEG8 (compound 16e) is a PEG-based PROTAC linker can be used in the synthesis of PROTACs.

  • CAS Number: 1092554-87-4
  • MF: C22H38O9
  • MW: 446.532
  • Catalog: PROTAC Linker
  • Density: 1.1±0.1 g/cm3
  • Boiling Point: 495.5±40.0 °C at 760 mmHg
  • Melting Point: N/A
  • Flash Point: 187.0±27.2 °C

Ald-Ph-PEG2-amine TFA

Ald-Ph-amido-C2-PEG2-amine is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

  • CAS Number: 2055013-56-2
  • MF: C14H20N2O4
  • MW: 280.32
  • Catalog: PROTAC Linker
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A

M-Peg3-sulfone-peg3-t-butyl ester

m-PEG3-Sulfone-PEG3-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

  • CAS Number: 2055041-00-2
  • MF: C20H40O10S
  • MW: 472.59
  • Catalog: PROTAC Linker
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A

NH-bis(C1-PEG1-Boc)

NH-bis(C1-PEG1-Boc) is an alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs[1].

  • CAS Number: 2171072-53-8
  • MF: C17H33NO6
  • MW: 347.45
  • Catalog: PROTAC Linker
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A

Mal-PEG2-amine TFA

Mal-PEG2-NH2 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

  • CAS Number: 660843-22-1
  • MF: C10H16N2O4
  • MW: 228.25
  • Catalog: PROTAC Linker
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A

Mal-PEG4-Glu(OH)-NH-m-PEG24

Mal-PEG4-Glu(OH)-NH-m-PEG24 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

  • CAS Number: 2204309-09-9
  • MF: C72H134N4O35
  • MW: 1615.84
  • Catalog: PROTAC Linker
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A

L-Azidohomoalanine hydrochloride

L-Azidohomoalanine hydrochloride is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1].

  • CAS Number: 942518-29-8
  • MF: C4H9ClN4O2
  • MW: 180.59300
  • Catalog: PROTAC Linker
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A

Alkynyl myristic acid

Alkynyl myristic acid is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1].

  • CAS Number: 82909-47-5
  • MF: C14H24O2
  • MW: 224.339
  • Catalog: PROTAC Linker
  • Density: 0.9±0.1 g/cm3
  • Boiling Point: 341.6±15.0 °C at 760 mmHg
  • Melting Point: N/A
  • Flash Point: 165.8±15.1 °C

Propargyl-PEG10-amine

Propargyl-PEG10-amine is a PEG-based PROTAC linker can be used in the synthesis of PROTACs.

  • CAS Number: 2112737-25-2
  • MF: C23H45NO10
  • MW: 495.60
  • Catalog: PROTAC Linker
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A

5-(Biotinamido)pentylazide

5-Biotinamidopentylazide is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1].

  • CAS Number: 1349190-76-6
  • MF: C15H26N6O2S
  • MW: 354.47
  • Catalog: PROTAC Linker
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A

tert-Butyl 11-aminoundecanoate

tert-Butyl 11-aminoundecanoate (compound 6b) is a PROTAC linker, which refers to the PEG composition. tert-Butyl 11-aminoundecanoate can be used in the synthesis of a series of PROTACs. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

  • CAS Number: 220851-29-6
  • MF: C15H31NO2
  • MW: 257.41200
  • Catalog: PROTAC Linker
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A

Azido-PEG2-alcohol

Azido-PEG2-alcohol is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

  • CAS Number: 139115-90-5
  • MF: C4H9N3O2
  • MW: 131.13300
  • Catalog: PROTAC Linker
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A

N,N-Diethanol amine-PEG4-Boc

N,N-Diethanol amine-PEG4-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

  • CAS Number: 2279944-66-8
  • MF: C19H39NO8
  • MW: 409.51
  • Catalog: PROTAC Linker
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A

Fmoc-Val-Phe-Boc

Fmoc-Val-Phe-Boc is a PROTAC linker and a maleimide-GGFG peptide linker. Fmoc-Val-Phe-Boc can be used in the synthesis of the Deruxtecan[1].

  • CAS Number: 258879-48-0
  • MF: C33H38N2O5
  • MW: 542.67
  • Catalog: PROTAC Linker
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A

Bis-Mal-Lysine-PEG4-acid

Bis-Mal-Lysine-PEG4-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

  • CAS Number: 1426164-52-4
  • MF: C31H45N5O13
  • MW: 695.71
  • Catalog: PROTAC Linker
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A

Tos-PEG2-CH2COOH

Tos-PEG2-CH2COOH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

  • CAS Number: 1807537-35-4
  • MF: C13H18O7S
  • MW: 318.343
  • Catalog: PROTAC Linker
  • Density: 1.3±0.1 g/cm3
  • Boiling Point: 512.8±40.0 °C at 760 mmHg
  • Melting Point: N/A
  • Flash Point: 263.9±27.3 °C

BCN-exo-PEG3-NH2

BCN-​exo-​PEG3-​NH2 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

  • CAS Number: 1841134-72-2
  • MF: C19H32N2O5
  • MW: 368.47
  • Catalog: PROTAC Linker
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A

Boc-PEG2-ethoxyethane-PEG2-benzyl

Boc-PEG2-ethoxyethane-PEG2-benzyl is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

  • CAS Number: 2111836-22-5
  • MF: C25H42O7
  • MW: 454.60
  • Catalog: PROTAC Linker
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A