Alkynyl myristic acid

Modify Date: 2024-01-11 22:24:42

Alkynyl myristic acid Structure
Alkynyl myristic acid structure
Common Name Alkynyl myristic acid
CAS Number 82909-47-5 Molecular Weight 224.339
Density 0.9±0.1 g/cm3 Boiling Point 341.6±15.0 °C at 760 mmHg
Molecular Formula C14H24O2 Melting Point N/A
MSDS N/A Flash Point 165.8±15.1 °C

 Use of Alkynyl myristic acid


Alkynyl myristic acid is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1].

 Names

Name tetradec-13-ynoic acid
Synonym More Synonyms

 Alkynyl myristic acid Biological Activity

Description Alkynyl myristic acid is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Related Catalog
Target

Alkyl-Chain

In Vitro PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

 Chemical & Physical Properties

Density 0.9±0.1 g/cm3
Boiling Point 341.6±15.0 °C at 760 mmHg
Molecular Formula C14H24O2
Molecular Weight 224.339
Flash Point 165.8±15.1 °C
Exact Mass 224.177628
PSA 37.30000
LogP 4.74
Vapour Pressure 0.0±1.6 mmHg at 25°C
Index of Refraction 1.469

 Synthetic Route

~88%

Alkynyl myristic acid Structure

Alkynyl myristi...

CAS#:82909-47-5

Literature: Menger; Chen; Brocchini; Hopkins; Hamilton Journal of the American Chemical Society, 1993 , vol. 115, # 15 p. 6600 - 6608

~%

Alkynyl myristic acid Structure

Alkynyl myristi...

CAS#:82909-47-5

Literature: Menger; Chen; Brocchini; Hopkins; Hamilton Journal of the American Chemical Society, 1993 , vol. 115, # 15 p. 6600 - 6608

~%

Alkynyl myristic acid Structure

Alkynyl myristi...

CAS#:82909-47-5

Literature: Menger; Chen; Brocchini; Hopkins; Hamilton Journal of the American Chemical Society, 1993 , vol. 115, # 15 p. 6600 - 6608

~%

Alkynyl myristic acid Structure

Alkynyl myristi...

CAS#:82909-47-5

Literature: Hebert; Beck; Lennox; Just Journal of Organic Chemistry, 1992 , vol. 57, # 6 p. 1777 - 1783

~%

Alkynyl myristic acid Structure

Alkynyl myristi...

CAS#:82909-47-5

Literature: Kraft; Popowa Zhurnal Obshchei Khimii, 1957 , vol. 27, p. 906;engl.Ausg.S.987

~%

Alkynyl myristic acid Structure

Alkynyl myristi...

CAS#:82909-47-5

Literature: Kraft; Popowa Zhurnal Obshchei Khimii, 1957 , vol. 27, p. 906;engl.Ausg.S.987

~%

Alkynyl myristic acid Structure

Alkynyl myristi...

CAS#:82909-47-5

Literature: Kraft; Popowa Zhurnal Obshchei Khimii, 1957 , vol. 27, p. 906;engl.Ausg.S.987

~%

Alkynyl myristic acid Structure

Alkynyl myristi...

CAS#:82909-47-5

Literature: Abrams, S. R. Canadian Journal of Chemistry, 1982 , vol. 60, p. 1238 - 1243

~%

Alkynyl myristic acid Structure

Alkynyl myristi...

CAS#:82909-47-5

Literature: Abrams, S. R. Canadian Journal of Chemistry, 1982 , vol. 60, p. 1238 - 1243

 Synonyms

13-Tetradecynoic acid
Myristic Acid Alkyne
Tetradec-13-ynoic acid
Tetradec-13-insaeure
13-Tetradecyn-1-oic acid