PROTAC Linker

Total: 1884
Updated: 2019-06-28 15:55:20
The PROTAC linker connects two moieties: a small peptide residue for E3 ubiquitin ligase recognition,and a ligand that can be recognized by a targeted protein. Unlike the small molecule ligands, the length of the linker has been randomly selected for PROTACs, varying from 12-carbon to over 20-carbon in length. An optimal linker will allow for maximal interaction between the two moieties (target protein and E3 ligase) resulting in efficient ubiquitination of the target protein and its ultimate degradation.
The PROTAC linker connects two moieties: a small peptide residue for E3 ubiquitin ligase recognition,and a ligand that can be recognized by a targeted protein. Unlike the small molecule ligands, the length of the linker has been randomly selected for PROTACs, varying from 12-carbon to over 20-carbon in length. An optimal linker will allow for maximal interaction between the two moieties (target protein and E3 ligase) resulting in efficient ubiquitination of the target protein and its ultimate degradation.
The PROTAC linker connects two moieties: a small peptide residue for E3 ubiquitin ligase recognition,and a ligand that can be recognized by a targeted protein. Unlike the small molecule ligands, the length of the linker has been randomly selected for PROTACs, varying from 12-carbon to over 20-carbon in length. An optimal linker will allow for maximal interaction between the two moieties (target protein and E3 ligase) resulting in efficient ubiquitination of the target protein and its ultimate degradation.
The PROTAC linker connects two moieties: a small peptide residue for E3 ubiquitin ligase recognition,and a ligand that can be recognized by a targeted protein. Unlike the small molecule ligands, the length of the linker has been randomly selected for PROTACs, varying from 12-carbon to over 20-carbon in length. An optimal linker will allow for maximal interaction between the two moieties (target protein and E3 ligase) resulting in efficient ubiquitination of the target protein and its ultimate degradation.

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PI3K/Akt/mTOR >
Akt AMPK ATM/ATR DNA-PK GSK-3 MELK mTOR PDK-1 PI3K PI4K PIKfyve PTEN
PROTAC >
PROTAC E3 Ligase Ligand-Linker Conjugate Ligand for E3 Ligase PROTAC Linker PROTAC-linker Conjugate for PAC
Protein Tyrosine Kinase/RTK >
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Vitamin D Related >
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Nonylbenzene-PEG5-OH

Nonylbenzene-PEG5-OH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

  • CAS Number: 20636-48-0
  • MF: C25H44O6
  • MW: 440.61300
  • Catalog: PROTAC Linker
  • Density: 1.016g/cm3
  • Boiling Point: 541.2ºC at 760 mmHg
  • Melting Point: N/A
  • Flash Point: 281.1ºC
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Benzyl-PEG1-Ms

Benzyl-PEG1-Ms is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

  • CAS Number: 58841-52-4
  • MF: C10H16O5S
  • MW: 248.29600
  • Catalog: PROTAC Linker
  • Density: 1.218g/cm3
  • Boiling Point: 375.438ºC at 760 mmHg
  • Melting Point: N/A
  • Flash Point: 180.858ºC
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H2n-peg14-oh

Amino-PEG14-alcohol is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

  • CAS Number: 34214-89-6
  • MF: C28H59NO14
  • MW: 633.77
  • Catalog: PROTAC Linker
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A
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DBCO-PEG1-amine

DBCO-PEG1-amine is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

  • CAS Number: 2364591-79-5
  • MF: C23H25N3O3
  • MW: 391.46
  • Catalog: PROTAC Linker
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A
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Triethylene glycol bis(p-toluenesulfonate)

Triethylene glycol bis(p-toluenesulfonate) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

  • CAS Number: 19249-03-7
  • MF: C20H26O8S2
  • MW: 458.546
  • Catalog: PROTAC Linker
  • Density: 1.3±0.1 g/cm3
  • Boiling Point: 608.4±55.0 °C at 760 mmHg
  • Melting Point: 78-82 °C(lit.)
  • Flash Point: 321.7±31.5 °C
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m-PEG4-sulfonic acid

m-PEG4-sulfonic acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

  • CAS Number: 787524-78-1
  • MF: C9H20O7S
  • MW: 272.316
  • Catalog: PROTAC Linker
  • Density: 1.2±0.1 g/cm3
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A
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Methyltetrazine-PEG5-NHS ester

Methyltetrazine-PEG5-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

  • CAS Number: 1802907-92-1
  • MF: C24H31N5O9
  • MW: 533.53
  • Catalog: PROTAC Linker
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A
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mPEG16-Br

m-PEG16-Br is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

  • CAS Number: 1238189-11-1
  • MF: C33H67BrO16
  • MW: 799.78
  • Catalog: PROTAC Linker
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A
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t-Boc-N-Amido-PEG5-propargyl

Boc-NH-PEG5-propargyl is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

  • CAS Number: 2062663-67-4
  • MF: C18H33NO7
  • MW: 375.46
  • Catalog: PROTAC Linker
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A
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Azido-PEG10-acid

Azido-PEG10-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A
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Tos-PEG12-Tos

Tos-PEG12-Tos is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

  • CAS Number: 1456708-45-4
  • MF: C38H62O17S2
  • MW: 855.019
  • Catalog: PROTAC Linker
  • Density: 1.2±0.1 g/cm3
  • Boiling Point: 833.3±65.0 °C at 760 mmHg
  • Melting Point: N/A
  • Flash Point: 457.8±34.3 °C
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Biotin-PEG2-C4-alkyne

Biotin-PEG2-C4-alkyne is a PEG-based PROTAC linker can be used in the synthesis of PROTACs.

  • CAS Number: 1011268-28-2
  • MF: C22H36N4O5S
  • MW: 468.610
  • Catalog: PROTAC Linker
  • Density: 1.2±0.1 g/cm3
  • Boiling Point: 799.8±60.0 °C at 760 mmHg
  • Melting Point: N/A
  • Flash Point: 437.5±32.9 °C
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Fmoc-N-amido-PEG2-alcohol

Fmoc-N-amido-PEG2-alcohol is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

  • CAS Number: 299430-87-8
  • MF: C19H21NO4
  • MW: 327.37400
  • Catalog: PROTAC Linker
  • Density: 1.221g/cm3
  • Boiling Point: 547.8ºC at 760 mmHg
  • Melting Point: N/A
  • Flash Point: 285.1ºC
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N-(Amino-PEG4)-N-Biotin-PEG4-acid

N-(Amino-PEG4)-N-Biotin-PEG4-acid is a biotin-labeled, PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

  • CAS Number: 2100306-84-9
  • MF: C31H58N4O12S
  • MW: 710.88
  • Catalog: PROTAC Linker
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A
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Acid-PEG2-C2-Boc

Acid-PEG2-C2-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

  • CAS Number: 2086688-99-3
  • MF: C12H22O6
  • MW: 262.3
  • Catalog: PROTAC Linker
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A
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Mal-PEG24-NHS ester

Mal-PEG24-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

  • CAS Number: 2226733-37-3
  • MF: C16H19N3O8
  • MW: 381.34
  • Catalog: PROTAC Linker
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A
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Cl-PEG6-acid

Cl-PEG6-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

  • CAS Number: 2365309-92-6
  • MF: C14H27ClO8
  • MW: 358.81
  • Catalog: PROTAC Linker
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A
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(+)-Biotin-ONP

(+)-Biotin-ONP is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1].

  • CAS Number: 33755-53-2
  • MF: C16H19N3O5S
  • MW: 365.404
  • Catalog: PROTAC Linker
  • Density: 1.3±0.1 g/cm3
  • Boiling Point: 642.9±50.0 °C at 760 mmHg
  • Melting Point: 163-165ºC
  • Flash Point: 342.6±30.1 °C
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Bromo-PEG3-THP

Bromo-PEG3-THP is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

  • CAS Number: 220568-33-2
  • MF: C11H21BrO4
  • MW: 297.19
  • Catalog: PROTAC Linker
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A
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Fmoc-amino-PEG3-CH2COOH

Fmoc-amino-PEG3-CH2COOH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

  • CAS Number: 139338-72-0
  • MF: C23H27NO7
  • MW: 429.463
  • Catalog: PROTAC Linker
  • Density: 1.3±0.1 g/cm3
  • Boiling Point: 651.1±65.0 °C at 760 mmHg
  • Melting Point: 46℃
  • Flash Point: 347.6±34.3 °C
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2,5-Dioxopyrrolidin-1-yl 2,2-dimethyl-4-oxo-3,8,11,14-tetraoxa-5-azaheptadecan-17-oate

Boc-NH-PEG3-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

  • CAS Number: 2250216-93-2
  • MF: C18H30N2O9
  • MW: 418.44
  • Catalog: PROTAC Linker
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A
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m-PEG7-4-nitrophenyl carbonate

m-PEG7-4-nitrophenyl carbonate is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

  • CAS Number: 678150-56-6
  • MF: C20H31NO11
  • MW: 461.46
  • Catalog: PROTAC Linker
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A
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Methyl azetidine-3-carboxylate hydrochloride

Methyl azetidine-3-carboxylate hydrochloride is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Methyl azetidine-3-carboxylate hydrochloride is also a alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs<

  • CAS Number: 100202-39-9
  • MF: C5H10ClNO2
  • MW: 151.591
  • Catalog: ADC Linker
  • Density: N/A
  • Boiling Point: 190.9ºC at 760 mmHg
  • Melting Point: 93.0 to 97.0 °C
  • Flash Point: 69.3ºC
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M-Peg3-sulfone-peg2-oh

m-PEG3-Sulfone-PEG3 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

  • CAS Number: 1919045-00-3
  • MF: C13H28O8S
  • MW: 344.42
  • Catalog: PROTAC Linker
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A
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Benzyl-PEG5-azide

Benzyl-PEG5-azide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

  • CAS Number: 86770-72-1
  • MF: C17H27N3O5
  • MW: 353.413
  • Catalog: PROTAC Linker
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A
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NH2-C4-NH-Boc

NH2-C4-NH-Boc (compound 15) is a PROTAC linker, which refers to the Alkyl/ether composition. NH2-C4-NH-Boc can be used in the synthesis of a series of PROTACs. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

  • CAS Number: 68076-36-8
  • MF: C9H20N2O2
  • MW: 188.267
  • Catalog: PROTAC Linker
  • Density: 1.0±0.1 g/cm3
  • Boiling Point: 292.9±23.0 °C at 760 mmHg
  • Melting Point: N/A
  • Flash Point: 130.9±22.6 °C
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Azido-PEG3-C-Boc

Azido-PEG3-C-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

  • CAS Number: 172531-36-1
  • MF: C12H23N3O5
  • MW: 289.32800
  • Catalog: PROTAC Linker
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A
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Methylamino-PEG2-acid HCl

Methylamino-PEG2-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

  • CAS Number: 1807503-87-2
  • MF: C8H17NO4
  • MW: 191.225
  • Catalog: PROTAC Linker
  • Density: 1.1±0.1 g/cm3
  • Boiling Point: 310.2±27.0 °C at 760 mmHg
  • Melting Point: N/A
  • Flash Point: 141.4±23.7 °C
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Azido-PEG12-NHS ester

Azido-PEG12-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

  • CAS Number: 2363756-50-5
  • MF: C31H56N4O16
  • MW: 740.79
  • Catalog: PROTAC Linker
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A
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Cl-C6-PEG4-O-CH2COOH

PROTAC Linker 4 is a PROTAC linker can be used in the synthesis of chloroalkane-containing PROTACs (HaloPROTACs).

  • CAS Number: 1799506-30-1
  • MF: C16H31ClO7
  • MW: 370.87
  • Catalog: PROTAC Linker
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A
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